Event extraction for the biomedical domain is more challenging than that in the general news domain since it requires broader acquisition of domain-specific knowledge and deeper understanding of complex contexts. To better encode contextual information and external background knowledge, we propose a novel knowledge base (KB)-driven tree-structured long short-term memory networks (Tree-LSTM) framework, incorporating two new types of features: (1) dependency structures to capture wide contexts; (2) entity properties (types and category descriptions) from external ontologies via entity linking. We evaluate our approach on the BioNLP shared task with Genia dataset and achieve a new state-of-the-art result. In addition, both quantitative and qualitative studies demonstrate the advancement of the Tree-LSTM and the external knowledge representation for biomedical event extraction.

In this paper we tackle two unique challenges in biomedical relation extraction. The first challenge is that the contextual information between two entity mentions often involves sophisticated syntactic structures. We propose a novel graph convolutional networks model that incorporates dependency parsing and contextualized embedding to effectively capture comprehensive contextual information. The second challenge is that most of the benchmark data sets for this task are quite imbalanced because more than 80% mention pairs are negative instances (i.e., no relations). We propose a multi-task learning framework to jointly model relation identification and classification tasks to propagate supervision signals from each other and apply a focal loss to focus training on ambiguous mention pairs. By applying these two strategies, experiments show that our model achieves state-of-the-art F-score on the 2013 drug-drug interaction extraction task.