Eeyore: Realistic Depression Simulation via Expert-in-the-Loop Supervised and Preference Optimization

Siyang Liu, Bianca Brie, Wenda Li, Laura Biester, Andrew Lee, James Pennebaker, Rada Mihalcea


Abstract
Large Language Models (LLMs) have been previously explored for mental healthcare training and therapy client simulation, but they still fall short in authentically capturing diverse client traits and psychological conditions. We introduce Eeyore , an 8B model optimized for realistic depression simulation through a structured alignment framework, incorporating expert input at every stage.First, we systematically curate real-world depression-related conversations, extracting depressive traits to guide data filtering and psychological profile construction, and use this dataset to instruction-tune Eeyore for profile adherence. Next, to further enhance realism, Eeyore undergoes iterative preference optimization—first leveraging model-generated preferences and then calibrating with a small set of expert-annotated preferences.Throughout the entire pipeline, we actively collaborate with domain experts, developing interactive interfaces to validate trait extraction and iteratively refine structured psychological profiles for clinically meaningful role-play customization.Despite its smaller model size, the Eeyore depression simulation outperforms GPT-4o with SOTA prompting strategies, both in linguistic authenticity and profile adherence.
Anthology ID:
2025.findings-acl.707
Volume:
Findings of the Association for Computational Linguistics: ACL 2025
Month:
July
Year:
2025
Address:
Vienna, Austria
Editors:
Wanxiang Che, Joyce Nabende, Ekaterina Shutova, Mohammad Taher Pilehvar
Venue:
Findings
SIG:
Publisher:
Association for Computational Linguistics
Note:
Pages:
13750–13770
Language:
URL:
https://preview.aclanthology.org/transition-to-people-yaml/2025.findings-acl.707/
DOI:
10.18653/v1/2025.findings-acl.707
Bibkey:
Cite (ACL):
Siyang Liu, Bianca Brie, Wenda Li, Laura Biester, Andrew Lee, James Pennebaker, and Rada Mihalcea. 2025. Eeyore: Realistic Depression Simulation via Expert-in-the-Loop Supervised and Preference Optimization. In Findings of the Association for Computational Linguistics: ACL 2025, pages 13750–13770, Vienna, Austria. Association for Computational Linguistics.
Cite (Informal):
Eeyore: Realistic Depression Simulation via Expert-in-the-Loop Supervised and Preference Optimization (Liu et al., Findings 2025)
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PDF:
https://preview.aclanthology.org/transition-to-people-yaml/2025.findings-acl.707.pdf