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# Abani Naik

Research Associate, Senior
Integrative Immunobiology
abani.naik@duke.edu
207 Research Drive, Jones Bldg, Room 316, Po 3010, Durham, NC 27710
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## Selected Publications

### Hierarchical assembly and disassembly of a transcriptionally active RAG locus in CD4+CD8+ thymocytes.

Journal Article J Exp Med · January 7, 2019 Expression of Rag1 and Rag2 is tightly regulated in developing T cells to mediate TCR gene assembly. Here we have investigated the molecular mechanisms governing the assembly and disassembly of a transcriptionally active RAG locus chromatin hub in CD4+CD8+ ... Full text Link to item Cite

### An anti-silencer- and SATB1-dependent chromatin hub regulates Rag1 and Rag2 gene expression during thymocyte development.

Journal Article J Exp Med · May 4, 2015 Rag1 and Rag2 gene expression in CD4(+)CD8(+) double-positive (DP) thymocytes depends on the activity of a distant anti-silencer element (ASE) that counteracts the activity of an intergenic silencer. However, the mechanistic basis for ASE activity is unkno ... Full text Link to item Cite

### Specification of Vδ and Vα usage by Tcra/Tcrd locus V gene segment promoters.

Journal Article J Immunol · January 15, 2015 The Tcra/Tcrd locus undergoes V-Dδ-Jδ rearrangement in CD4(-)CD8(-) thymocytes to form the TCRδ chain of the γδ TCR and V-Jα rearrangement in CD4(+)CD8(+) thymocytes to form the TCRα-chain of the αβ TCR. Most V segments in the locus participate in V-Jα rea ... Full text Link to item Cite

### Differential Reaction Kinetics, Cleavage Complex Formation, and Nonamer Binding Domain Dependence Dictate the Structure-Specific and Sequence-Specific Nuclease Activity of RAGs

Journal Article Journal of Molecular Biology · January 20, 2012 Full text Link to item Cite

### Cytosines, but Not Purines, Determine Recombination Activating Gene (RAG)-induced Breaks on Heteroduplex DNA Structures

Journal Article Journal of Biological Chemistry · March 2010 Full text Cite

### P1 nuclease cleavage is dependent on length of the mismatches in DNA

Journal Article DNA Repair · August 2008 Full text Cite