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# Christopher Dale Kontos

Professor of Medicine
Medicine, Cardiology
cdkontos@duke.edu
Duke Box 102148, Durham, NC 27710
180A CARL Bldg, 213 Research Dr., Durham, NC 27710
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## Overview

The Kontos Lab studies the molecular mechanisms of angiogenesis and vascular remodeling. Studies are directed toward understanding how signal transduction by endothelial receptor tyrosine kinase (RTKs) regulates vascular growth in both physiological and pathological processes, including exercise, peripheral artery disease (PAD), atherosclerosis, and cancer.
Current projects include:
1. Signal transduction, mechanisms of activation, and downregulation of endothelial RTKs (mainly Tie1, Tie2, VEGFR-1, and VEGFR-2)
2. Differential effects of the Angiopoietins
3. Role of the inositol phosphatase PTEN in the regulation of vascular cell growth and remodeling
4. PTEN gene therapy for prevention of vein graft disease
5. Angiogenic signaling in skeletal muscle, including mechanisms of exercise-induced angiogenesis
6. Proteolytic cleavage and shedding of endothelial RTKs
7. Angiogenic proteins as biomarkers in peripheral artery disease

## Current Appointments & Affiliations

Professor of Medicine · 2017 - Present Medicine, Cardiology, Medicine
Director, Medical Scientist Training Program · 2009 - Present Medicine, Cardiology, Medicine
Professor of Pharmacology and Cancer Biology · 2017 - Present Pharmacology & Cancer Biology, Basic Science Departments
Professor of Cell Biology · 2022 - Present Cell Biology, Basic Science Departments
Member of the Duke Cancer Institute · 1993 - Present Duke Cancer Institute, Institutes and Centers

## Education, Training & Certifications

Virginia Commonwealth University · 1989 M.D.