# Edward L. Keller

### Research Areas

- Computational neuroscience; bioengineering; neurophysiology of the oculomotor system

## Biography

Prof. Edward L. Keller received the BS degree in Engineering Science from the U.S. Naval Academy in 1961 and served as a U.S. naval officer from 1961-1965; subsequently, he received the Ph.D. degree in Bioengineering from Johns Hopkins University in 1971.

He joined the EECS Department faculty in 1971. In 1977-78, he was a Visiting Professor at the Max Planck Institute for Brain Research in Frankfurt, Germany; chaired the campus Engineering Science Program from 1988-1994; served as Chair of the Joint UC Berkeley/UC San Francisco Graduate Group in Bioengineering for one year in 1989; and in 1989-1990, was a Visiting Scientist at the National Institutes of Health in Bethesda, MD. After retiring from the University as an Emeritus Professor in 1994, he became Associate Director of the Smith-Kettlewell Eye Research Institute in San Francisco where his laboratory conducts research on how the brain converts sensory inputs into appropriate signals to generate motor behavior. Specifically, most of his research is involved in uncovering the structural and functional organizations in the nervous system that carry out spatiotemporal transformations, using the saccadic system as a model.

Prof. Keller is a Fellow of the IEEE.

## Education

- 1971, Ph.D., Biomedical Engineering, Johns Hopkins University
- 1961, B.S., Engineering Science, U.S. Naval Academy

## Selected Publications

- P. D. Thiem, E. L. Keller, and K. Lee, "Psychophysical evidence that top-down input effects error directions in a choice-response saccade task," J. Vision, vol. 6, no. 6, pp. 487a, June 2006.
- K. M. Lee and E. L. Keller, "Symbolic cue driven activity in superior colliculus neurons in a peripheral visual choice task," J. Neurophysiology, vol. 95, no. 6, pp. 3585-3595, June 2006.
- K. Lee, E. L. Keller, and S. J. Heinen, "Properties of saccades generated as a choice response," Experimental Brain Research, vol. 162, no. 3, pp. 278-286, April 2005.
- E. L. Keller, K. Lee, and R. M. McPeek, "Readout of higher-level processing in the discharge of superior colliculus neurons," Annals of the New York Academy of Science, vol. 1039, pp. 198-208, April 2005.
- K. Arai and E. L. Keller, "A model of the saccade-generating system that accounts for trajectory variations produced by copeting visual stimuli," Biological Cybernetics, vol. 92, no. 1, pp. 21-37, Jan. 2005.
- K. Arai and E. L. Keller, "A distributed model of the saccadic system: Simulations of trajectory variations produced by multiple competing visual stimuli," in Proc. 26th Annual Intl. Conf. of the IEEE Engineering in Medicine and Biology Society, Vol. 7, Piscataway, NJ: IEEE Press, 2004, pp. 4692-4695.
- R. M. McPeek and E. L. Keller, "Deficits in saccade target selection after inactivation of superior colliculus," Nature Neuroscience, vol. 7, no. 7, pp. 757-763, July 2004.
- R. W. Anderson, S. Das, and E. L. Keller, "Estimation of spatiotemporal neural activity using radial basis function networks," J. Computational Neuroscience, vol. 5, no. 4, pp. 421-441, Oct. 1998.
- D. C. Deno, E. L. Keller, and W. F. Crandall, "Dynamical neural network organization of the visual pursuit system," IEEE Trans. Biomedical Engineering, vol. 36, no. 1, pp. 85-92, Jan. 1989.
- E. L. Keller, "Participation of medial pontine reticular formation in eye movement generation in monkey," J. Neurophysiology, vol. 37, no. 2, pp. 316-332, March 1974.