Despite their general capabilities, LLMs still struggle on biomedicalNER tasks, which are difficult due to the presence of specialized terminology and lack of training data. In this work we set out to improve LLM performance on biomedical NER in limited data settings via a new knowledge augmentation approach which incorporates definitions of relevant concepts on-the-fly. During this process, to provide a test bed for knowledge augmentation, we perform a comprehensive exploration of prompting strategies. Our experiments show that definition augmentation is useful for both open source and closed LLMs.For example, it leads to a relative improvement of 15% (on average) in GPT-4 performance (F1) across all (six) of our test datasets. We conduct extensive ablations and analyses to demonstrate that our performance improvements stem from adding relevant definitional knowledge. We find that careful prompting strategies also improve LLM performance, allowing them to outperform fine-tuned language models in few-shot settings. To facilitate future research in this direction, we release our code at https://github.com/allenai/beacon.

Extracting fine-grained experimental findings from literature can provide dramatic utility for scientific applications. Prior work has developed annotation schemas and datasets for limited aspects of this problem, failing to capture the real-world complexity and nuance required. Focusing on biomedicine, this work presents CARE—a new IE dataset for the task of extracting clinical findings. We develop a new annotation schema capturing fine-grained findings as n-ary relations between entities and attributes, which unifies phenomena challenging for current IE systems such as discontinuous entity spans, nested relations, variable arity n-ary relations and numeric results in a single schema. We collect extensive annotations for 700 abstracts from two sources: clinical trials and case reports. We also demonstrate the generalizability of our schema to the computer science and materials science domains. We benchmark state-of-the-art IE systems on CARE, showing that even models such as GPT4 struggle. We release our resources to advance research on extracting and aggregating literature findings.

Due to the rapid growth of publications varying in quality, there exists a pressing need to help scientists digest and evaluate relevant papers, thereby facilitating scientific discovery. This creates a number of urgent questions; however, computer-human collaboration in the scientific paper lifecycle is still in the exploratory stage and lacks a unified framework for analyzing the relevant tasks. Additionally, with the recent significant success of large language models (LLMs), they have increasingly played an important role in academic writing. In this cutting-edge tutorial, we aim to provide an all-encompassing overview of the paper lifecycle, detailing how machines can augment every stage of the research process for the scientist, including scientific literature understanding, experiment development, manuscript draft writing, and finally draft evaluation. This tutorial is devised for researchers interested in this rapidly-developing field of NLP-augmented paper writing. The tutorial will also feature a session of hands-on exercises during which participants can guide machines in generating ideas and automatically composing key paper elements. Furthermore, we will address current challenges, explore future directions, and discuss potential ethical issues. A toolkit designed for human-computer collaboration throughout the paper lifecycle will also be made publically available.

We explore and enhance the ability of neural language models to generate novel scientific directions grounded in literature. Work on literature-based hypothesis generation has traditionally focused on binary link prediction—severely limiting the expressivity of hypotheses. This line of work also does not focus on optimizing novelty. We take a dramatic departure with a novel setting in which models use as input background contexts (e.g., problems, experimental settings, goals), and output natural language ideas grounded in literature. We present SciMON, a modeling framework that uses retrieval of “inspirations” from past scientific papers, and explicitly optimizes for novelty by iteratively comparing to prior papers and updating idea suggestions until sufficient novelty is achieved. Comprehensive evaluations reveal that GPT-4 tends to generate ideas with overall low technical depth and novelty, while our methods partially mitigate this issue. Our work represents a first step toward evaluating and developing language models that generate new ideas derived from the scientific literature. Code, data, and resources are publicly available for research purposes: https://github.com/eaglew/clbd.

We introduce the task of automatically revising scientific papers based on peer feedback and release ARIES, a dataset of review comments and their corresponding paper edits. The data is drawn from real reviewer-author interactions from computer science, and we provide labels linking each reviewer comment to the specific paper edits made by the author in response. We automatically create a high-precision silver training set, as well as an expert-labeled test set that shows high inter-annotator agreement. In experiments with 10 models covering the state of the art, we find that they struggle even to identify which edits correspond to a comment—especially when the relationship between the edit and the comment is indirect and requires reasoning to uncover. We also extensively analyze GPT-4’s ability to generate edits given a comment and the original paper. We find that it often succeeds on a superficial level, but tends to rigidly follow the wording of the feedback rather than the underlying intent, and lacks technical details compared to human-written edits.

Adapting pretrained language models to novel domains, such as clinical applications, traditionally involves retraining their entire set of parameters. Parameter-Efficient Fine-Tuning (PEFT) techniques for fine-tuning language models significantly reduce computational requirements by selectively fine-tuning small subsets of parameters. In this study, we propose a two-step PEFT framework and evaluate it in the clinical domain. Our approach combines a specialised PEFT adapter layer designed for clinical domain adaptation with another adapter specialised for downstream tasks. We evaluate the framework on multiple clinical outcome prediction datasets, comparing it to clinically trained language models. Our framework achieves a better AUROC score averaged across all clinical downstream tasks compared to clinical language models. In particular, we observe large improvements of 4-5% AUROC in large-scale multilabel classification tasks, such as diagnoses and procedures classification. To our knowledge, this study is the first to provide an extensive empirical analysis of the interplay between PEFT techniques and domain adaptation in an important real-world domain of clinical applications.

With the recent advances in natural language processing (NLP), a vast number of applications have emerged across various use cases. Among the plethora of NLP applications, many academic researchers are motivated to do work that has a positive social impact, in line with the recent initiatives of NLP for Social Good (NLP4SG). However, it is not always obvious to researchers how their research efforts are tackling today’s big social problems. Thus, in this paper, we introduce NLP4SGPapers, a scientific dataset with three associated tasks that can help identify NLP4SG papers and characterize the NLP4SG landscape by: (1) identifying the papers that address a social problem, (2) mapping them to the corresponding UN Sustainable Development Goals (SDGs), and (3) identifying the task they are solving and the methods they are using. Using state-of-the-art NLP models, we address each of these tasks and use them on the entire ACL Anthology, resulting in a visualization workspace that gives researchers a comprehensive overview of the field of NLP4SG. Our website is available at https://nlp4sg.vercel.app . We released our data at https://huggingface.co/datasets/feradauto/NLP4SGPapers and code at https://github.com/feradauto/nlp4sg

Various NLP tasks require a complex hierarchical structure over nodes, where each node is a cluster of items. Examples include generating entailment graphs, hierarchical cross-document coreference resolution, annotating event and subevent relations, etc. To enable efficient annotation of such hierarchical structures, we release CHAMP, an open source tool allowing to incrementally construct both clusters and hierarchy simultaneously over any type of texts. This incremental approach significantly reduces annotation time compared to the common pairwise annotation approach and also guarantees maintaining transitivity at the cluster and hierarchy levels. Furthermore, CHAMP includes a consolidation mode, where an adjudicator can easily compare multiple cluster hierarchy annotations and resolve disagreements.

Systems that automatically define unfamiliar terms hold the promise of improving the accessibility of scientific texts, especially for readers who may lack prerequisite background knowledge. However, current systems assume a single “best” description per concept, which fails to account for the many ways a concept can be described. We present ACCoRD, an end-to-end system tackling the novel task of generating sets of descriptions of scientific concepts. Our system takes advantage of the myriad ways a concept is mentioned across the scientific literature to produce distinct, diverse descriptions oftarget concepts in terms of different reference concepts. In a user study, we find that users prefer (1) descriptions produced by our end-to-end system, and (2) multiple descriptions to a single “best” description. We release the ACCoRD corpus which includes 1,275 labeled contexts and 1,787 expert-authored concept descriptions to support research on our task.

We present BEEP (Biomedical Evidence-Enhanced Predictions), a novel approach for clinical outcome prediction that retrieves patient-specific medical literature and incorporates it into predictive models. Based on each individual patient’s clinical notes, we train language models (LMs) to find relevant papers and fuse them with information from notes to predict outcomes such as in-hospital mortality. We develop methods to retrieve literature based on noisy, information-dense patient notes, and to augment existing outcome prediction models with retrieved papers in a manner that maximizes predictive accuracy. Our approach boosts predictive performance on three important clinical tasks in comparison to strong recent LM baselines, increasing F1 by up to 5 points and precision@Top-K by a large margin of over 25%.

Combination therapies have become the standard of care for diseases such as cancer, tuberculosis, malaria and HIV. However, the combinatorial set of available multi-drug treatments creates a challenge in identifying effective combination therapies available in a situation. To assist medical professionals in identifying beneficial drug-combinations, we construct an expert-annotated dataset for extracting information about the efficacy of drug combinations from the scientific literature. Beyond its practical utility, the dataset also presents a unique NLP challenge, as the first relation extraction dataset consisting of variable-length relations. Furthermore, the relations in this dataset predominantly require language understanding beyond the sentence level, adding to the challenge of this task. We provide a promising baseline model and identify clear areas for further improvement. We release our dataset (https://huggingface.co/datasets/allenai/drug-combo-extraction), code (https://github.com/allenai/drug-combo-extraction) and baseline models (https://huggingface.co/allenai/drug-combo-classifier-pubmedbert-dapt) publicly to encourage the NLP community to participate in this task.

We present a new scientific document similarity model based on matching fine-grained aspects of texts. To train our model, we exploit a naturally-occurring source of supervision: sentences in the full-text of papers that cite multiple papers together (co-citations). Such co-citations not only reflect close paper relatedness, but also provide textual descriptions of how the co-cited papers are related. This novel form of textual supervision is used for learning to match aspects across papers. We develop multi-vector representations where vectors correspond to sentence-level aspects of documents, and present two methods for aspect matching: (1) A fast method that only matches single aspects, and (2) a method that makes sparse multiple matches with an Optimal Transport mechanism that computes an Earth Mover’s Distance between aspects. Our approach improves performance on document similarity tasks in four datasets. Further, our fast single-match method achieves competitive results, paving the way for applying fine-grained similarity to large scientific corpora.

The COVID-19 pandemic has spawned a diverse body of scientific literature that is challenging to navigate, stimulating interest in automated tools to help find useful knowledge. We pursue the construction of a knowledge base (KB) of mechanisms—a fundamental concept across the sciences, which encompasses activities, functions and causal relations, ranging from cellular processes to economic impacts. We extract this information from the natural language of scientific papers by developing a broad, unified schema that strikes a balance between relevance and breadth. We annotate a dataset of mechanisms with our schema and train a model to extract mechanism relations from papers. Our experiments demonstrate the utility of our KB in supporting interdisciplinary scientific search over COVID-19 literature, outperforming the prominent PubMed search in a study with clinical experts. Our search engine, dataset and code are publicly available.

While natural language understanding (NLU) is advancing rapidly, today’s technology differs from human-like language understanding in fundamental ways, notably in its inferior efficiency, interpretability, and generalization. This work proposes an approach to representation and learning based on the tenets of embodied cognitive linguistics (ECL). According to ECL, natural language is inherently executable (like programming languages), driven by mental simulation and metaphoric mappings over hierarchical compositions of structures and schemata learned through embodied interaction. This position paper argues that the use of grounding by metaphoric reasoning and simulation will greatly benefit NLU systems, and proposes a system architecture along with a roadmap towards realizing this vision.

The COVID-19 pandemic has sparked unprecedented mobilization of scientists, generating a deluge of papers that makes it hard for researchers to keep track and explore new directions. Search engines are designed for targeted queries, not for discovery of connections across a corpus. In this paper, we present SciSight, a system for exploratory search of COVID-19 research integrating two key capabilities: first, exploring associations between biomedical facets automatically extracted from papers (e.g., genes, drugs, diseases, patient outcomes); second, combining textual and network information to search and visualize groups of researchers and their ties. SciSight has so far served over 15K users with over 42K page views and 13% returns.