We propose ProtLLM, a versatile cross-modal large language model (LLM) for both protein-centric and protein-language tasks. ProtLLM features a unique dynamic protein mounting mechanism, enabling it to handle complex inputs where the natural language text is interspersed with an arbitrary number of proteins. Besides, we propose the protein-as-word language modeling approach to train ProtLLM. By developing a specialized protein vocabulary, we equip the model with the capability to predict not just natural language but also proteins from a vast pool of candidates. Additionally, we construct a large-scale interleaved protein-text dataset, named InterPT, for pre-training. This dataset comprehensively encompasses both (1) structured data sources like protein annotations and (2) unstructured data sources like biological research papers, thereby endowing ProtLLM with crucial knowledge for understanding proteins. We evaluate ProtLLM on classic supervised protein-centric tasks and explore its novel protein-language applications. Experimental results demonstrate that ProtLLM not only achieves superior performance against protein-specialized baselines on protein-centric tasks but also induces zero-shot and in-context learning capabilities on protein-language tasks.

Sentiment analysis has always been an important research direction in natural language processing. The research can be divided into explicit sentiment analysis and implicit sentiment analysis according to whether there are sentiment words in language expression. There have been many research results in explicit sentiment analysis. However, implicit sentiment analysis is rarely studied. Compared with explicit sentiment expression, implicit sentiment expression usually omits a lot of knowledge and common sense, and context also has an important impact on implicit sentiment expression. In this paper, we use a knowledge graph to supplement implicit sentiment expression and propose a novel Implicit Sentiment Analysis model combining Knowledge enhancement and Context features (dubbed KC-ISA). The KC-ISA model can effectively integrate external knowledge and contextual features by the coattention mechanism. Finally, we conduct experiments on the SMP2019 implicit sentiment analysis dataset. Moreover, to verify the generality of the model, we also conduct experiments on two common sentiment analysis datasets. The results on three datasets show that our proposed KC-ISA model can achieve better results on text sentiment analysis.