The Helsinki-NLP team participated in the AmericasNLP 2023 Shared Task with 6 submissions for all 11 language pairs arising from 4 different multilingual systems. We provide a detailed look at the work that went into collecting and preprocessing the data that led to our submissions. We explore various setups for multilingual Neural Machine Translation (NMT), namely knowledge distillation and transfer learning, multilingual NMT including a high-resource language (English), language-specific fine-tuning, and multilingual NMT exclusively using low-resource data. Our multilingual Model B ranks first in 4 out of the 11 language pairs.