The information bottleneck (IB) principle has been proven effective in various NLP applications.The existing work, however, only used either generative or information compression models to improve the performance of the target task. In this paper, we propose to combine the two types of IB models into one system to enhance Named Entity Recognition (NER).For one type of IB model, we incorporate two unsupervised generative components, span reconstruction and synonym generation, into a span-based NER system.The span reconstruction ensures that the contextualised span representation keeps the span information, while the synonym generation makes synonyms have similar representations even in different contexts. For the other type of IB model, we add a supervised IB layer that performs information compression into the system to preserve useful features for NER in the resulting span representations.Experiments on five different corpora indicate that jointly training both generative and information compression models can enhance the performance of the baseline span-based NER system.Our source code is publicly available at https://github.com/nguyennth/joint-ib-models.

We propose a distantly supervised pipeline NER which executes entity span detection and entity classification in sequence named DISTANT (DIstantly Supervised enTity spAN deTection and classification).The former entity span detector extracts possible entity mention spans by the distant supervision. Then the later entity classifier assigns each entity span to one of the positive entity types or none by employing a positive and unlabeled (PU) learning framework. Two models were built based on the pre-trained SciBERT model and fine-tuned with the silver corpus generated by the distant supervision.Experimental results on BC5CDR and NCBI-Disease datasets show that our method outperforms the end-to-end NER baselines without PU learning by a large margin. In particular, it increases the recall score effectively.

We propose a novel distantly supervised document-level biomedical relation extraction model that uses partial knowledge graphs that include the graph neighborhood of the entities appearing in each input document. Most conventional distantly supervised relation extraction methods use only the entity relations automatically annotated by using knowledge base entries. They do not fully utilize the rich information in the knowledge base, such as entities other than the target entities and the network of heterogeneous entities defined in the knowledge base. To address this issue, our model integrates the representations of the entities acquired from the neighborhood knowledge graphs with the representations of the input document. We conducted experiments on the ChemDisGene dataset using Comparative Toxicogenomics Database (CTD) for document-level relation extraction with respect to interactions between drugs, diseases, and genes. Experimental results confirmed the performance improvement by integrating entities and their neighborhood biochemical information from the knowledge base.

We propose a novel Biomedical domain-specific Non-AutoRegressive Transformer model for natural language generation: BioNART. Our BioNART is based on an encoder-decoder model, and both encoder and decoder are compatible with widely used BERT architecture, which allows benefiting from publicly available pre-trained biomedical language model checkpoints. We performed additional pre-training and fine-tuned BioNART on biomedical summarization and doctor-patient dialogue tasks. Experimental results show that our BioNART achieves about 94% of the ROUGE score to the pre-trained autoregressive model while realizing an 18 times faster inference speed on the iCliniq dataset.

Recently, several methods have tackled the relation extraction task with QA and have shown successful results. However, the effectiveness of existing methods in specific domains, such as the biomedical domain, is yet to be verified. When there are multiple entity pairs that share an entity in a sentence, a QA-based relation extraction model that outputs only one single answer to a given question may not extract desired relations. In addition, these methods employ QA models that are not tuned for relation extraction. To address these issues, we first extend and apply a span QA-based relation extraction method to the drug-protein relation extraction by creating question templates and incorporating entity type markers. We further propose a binary QA-based method that directly uses the entity information available in the relation extraction task. The experimental results on the DrugProt dataset show that our QA-based methods, especially the proposed binary QA method, are effective for drug-protein relation extraction.

This paper proposes a new document classification method that incorporates the representations of a literature graph created from bibliographic and entity information.Recently, document classification performance has been significantly improved with large pre-trained language models; however, there still remain documents that are difficult to classify. External information, such as bibliographic information, citation links, descriptions of entities, and medical taxonomies, has been considered one of the keys to dealing with such documents in document classification. Although several document classification methods using external information have been proposed, they only consider limited relationships, e.g., word co-occurrence and citation relationships. However, there are multiple types of external information.To overcome the limitation of the conventional use of external information, we propose a document classification model that simultaneously considers bibliographic and entity information to deeply model the relationships among documents using the representations of the literature graph.The experimental results show that our proposed method outperforms existing methods on two document classification datasets in the biomedical domain with the help of the literature graph.

This paper proposes novel drug-protein relation extraction models that indirectly utilize distant supervision data. Concretely, instead of adding distant supervision data to the manually annotated training data, our models incorporate distantly supervised models that are relation extraction models trained with distant supervision data. Distantly supervised learning has been proposed to generate a large amount of pseudo-training data at low cost. However, there is still a problem of low prediction performance due to the inclusion of mislabeled data. Therefore, several methods have been proposed to suppress the effects of noisy cases by utilizing some manually annotated training data. However, their performance is lower than that of supervised learning on manually annotated data because mislabeled data that cannot be fully suppressed becomes noise when training the model. To overcome this issue, our methods indirectly utilize distant supervision data with manually annotated training data. The experimental results on the DrugProt corpus in the BioCreative VII Track 1 showed that our proposed model can consistently improve the supervised models in different settings.

Cancer immunology research involves several important cell and protein factors. Extracting the information of such cells and proteins and the interactions between them from text are crucial in text mining for cancer immunology research. However, there are few available datasets for these entities, and the amount of annotated documents is not sufficient compared with other major named entity types. In this work, we introduce our automatically annotated dataset of key named entities, i.e., T-cells, cytokines, and transcription factors, which engages the recent cancer immunotherapy. The entities are annotated based on the UniProtKB knowledge base using dictionary matching. We build a neural named entity recognition (NER) model to be trained on this dataset and evaluate it on a manually-annotated data. Experimental results show that we can achieve a promising NER performance even though our data is automatically annotated. Our dataset also enhances the NER performance when combined with existing data, especially gaining improvement in yet investigated named entities such as cytokines and transcription factors.

Negation and uncertainty modeling are long-standing tasks in natural language processing. Linguistic theory postulates that expressions of negation and uncertainty are semantically independent from each other and the content they modify. However, previous works on representation learning do not explicitly model this independence. We therefore attempt to disentangle the representations of negation, uncertainty, and content using a Variational Autoencoder. We find that simply supervising the latent representations results in good disentanglement, but auxiliary objectives based on adversarial learning and mutual information minimization can provide additional disentanglement gains.

We propose a multi-task, probabilistic approach to facilitate distantly supervised relation extraction by bringing closer the representations of sentences that contain the same Knowledge Base pairs. To achieve this, we bias the latent space of sentences via a Variational Autoencoder (VAE) that is trained jointly with a relation classifier. The latent code guides the pair representations and influences sentence reconstruction. Experimental results on two datasets created via distant supervision indicate that multi-task learning results in performance benefits. Additional exploration of employing Knowledge Base priors into theVAE reveals that the sentence space can be shifted towards that of the Knowledge Base, offering interpretability and further improving results.

We present a biomedical entity linking (EL) system BENNERD that detects named enti- ties in text and links them to the unified medical language system (UMLS) knowledge base (KB) entries to facilitate the corona virus disease 2019 (COVID-19) research. BEN- NERD mainly covers biomedical domain, es- pecially new entity types (e.g., coronavirus, vi- ral proteins, immune responses) by address- ing CORD-NER dataset. It includes several NLP tools to process biomedical texts includ- ing tokenization, flat and nested entity recog- nition, and candidate generation and rank- ing for EL that have been pre-trained using the CORD-NER corpus. To the best of our knowledge, this is the first attempt that ad- dresses NER and EL on COVID-19-related entities, such as COVID-19 virus, potential vaccines, and spreading mechanism, that may benefit research on COVID-19. We release an online system to enable real-time entity annotation with linking for end users. We also release the manually annotated test set and CORD-NERD dataset for leveraging EL task. The BENNERD system is available at https://aistairc.github.io/BENNERD/.

We present a neural exhaustive approach that addresses named entity recognition (NER) and relation recognition (RE), for the entity and re- lation recognition over the wet-lab protocols shared task. We introduce BERT-based neural exhaustive approach that enumerates all pos- sible spans as potential entity mentions and classifies them into entity types or no entity with deep neural networks to address NER. To solve relation extraction task, based on the NER predictions or given gold mentions we create all possible trigger-argument pairs and classify them into relation types or no relation. In NER task, we achieved 76.60% in terms of F-score as third rank system among the partic- ipated systems. In relation extraction task, we achieved 80.46% in terms of F-score as the top system in the relation extraction or recognition task. Besides we compare our model based on the wet lab protocols corpus (WLPC) with the WLPC baseline and dynamic graph-based in- formation extraction (DyGIE) systems.

The synthesis process is essential for achieving computational experiment design in the field of inorganic materials chemistry. In this work, we present a novel corpus of the synthesis process for all-solid-state batteries and an automated machine reading system for extracting the synthesis processes buried in the scientific literature. We define the representation of the synthesis processes using flow graphs, and create a corpus from the experimental sections of 243 papers. The automated machine-reading system is developed by a deep learning-based sequence tagger and simple heuristic rule-based relation extractor. Our experimental results demonstrate that the sequence tagger with the optimal setting can detect the entities with a macro-averaged F1 score of 0.826, while the rule-based relation extractor can achieve high performance with a macro-averaged F1 score of 0.887.

This paper proposes an Ontology-Style Relation (OSR) annotation approach. In conventional Relation Extraction (RE) datasets, relations are annotated as links between entity mentions. In contrast, in our OSR annotation, a relation is annotated as a relation mention (i.e., not a link but a node) and domain and range links are annotated from the relation mention to its argument entity mentions. We expect the following benefits: (1) the relation annotations can be easily converted to Resource Description Framework (RDF) triples to populate an Ontology, (2) some part of conventional RE tasks can be tackled as Named Entity Recognition (NER) tasks. The relation classes are limited to several RDF properties such as domain, range, and subClassOf, and (3) OSR annotations can be clear documentations of Ontology contents. As a case study, we converted an in-house corpus of Japanese traffic rules in conventional annotations into the OSR annotations and built a novel OSR-RoR (Rules of the Road) corpus. The inter-annotator agreements of the conversion were 85-87%. We evaluated the performance of neural NER and RE tools on the conventional and OSR annotations. The experimental results showed that the OSR annotations make the RE task easier while introducing slight complexity into the NER task.

We tackle the nested and overlapping event detection task and propose a novel search-based neural network (SBNN) structured prediction model that treats the task as a search problem on a relation graph of trigger-argument structures. Unlike existing structured prediction tasks such as dependency parsing, the task targets to detect DAG structures, which constitute events, from the relation graph. We define actions to construct events and use all the beams in a beam search to detect all event structures that may be overlapping and nested. The search process constructs events in a bottom-up manner while modelling the global properties for nested and overlapping structures simultaneously using neural networks. We show that the model achieves performance comparable to the state-of-the-art model Turku Event Extraction System (TEES) on the BioNLP Cancer Genetics (CG) Shared Task 2013 without the use of any syntactic and hand-engineered features. Further analyses on the development set show that our model is more computationally efficient while yielding higher F1-score performance.

Document-level relation extraction is a complex human process that requires logical inference to extract relationships between named entities in text. Existing approaches use graph-based neural models with words as nodes and edges as relations between them, to encode relations across sentences. These models are node-based, i.e., they form pair representations based solely on the two target node representations. However, entity relations can be better expressed through unique edge representations formed as paths between nodes. We thus propose an edge-oriented graph neural model for document-level relation extraction. The model utilises different types of nodes and edges to create a document-level graph. An inference mechanism on the graph edges enables to learn intra- and inter-sentence relations using multi-instance learning internally. Experiments on two document-level biomedical datasets for chemical-disease and gene-disease associations show the usefulness of the proposed edge-oriented approach.

We present a neural pipeline approach that performs named entity recognition (NER) and concept indexing (CI), which links them to concept unique identifiers (CUIs) in a knowledge base, for the PharmaCoNER shared task on pharmaceutical drugs and chemical entities. We proposed a neural NER model that captures the surrounding semantic information of a given sequence by capturing the forward- and backward-context of bidirectional LSTM (Bi-LSTM) output of a target span using contextual span representation-based exhaustive approach. The NER model enumerates all possible spans as potential entity mentions and classify them into entity types or no entity with deep neural networks. For representing span, we compare several different neural network architectures and their ensembling for the NER model. We then perform dictionary matching for CI and, if there is no matching, we further compute similarity scores between a mention and CUIs using entity embeddings to assign the CUI with the highest score to the mention. We evaluate our approach on the two sub-tasks in the shared task. Among the five submitted runs, the best run for each sub-task achieved the F-score of 86.76% on Sub-task 1 (NER) and the F-score of 79.97% (strict) on Sub-task 2 (CI).

This paper describes our system developed for the coreference resolution task of the CRAFT Shared Tasks 2019. The CRAFT corpus is more challenging than other existing corpora because it contains full text articles. We have employed an existing span-based state-of-theart neural coreference resolution system as a baseline system. We enhance the system with two different techniques to capture longdistance coreferent pairs. Firstly, we filter noisy mentions based on parse trees with increasing the number of antecedent candidates. Secondly, instead of relying on the LSTMs, we integrate the highly expressive language model–BERT into our model. Experimental results show that our proposed systems significantly outperform the baseline. The best performing system obtained F-scores of 44%, 48%, 39%, 49%, 40%, and 57% on the test set with B3, BLANC, CEAFE, CEAFM, LEA, and MUC metrics, respectively. Additionally, the proposed model is able to detect coreferent pairs in long distances, even with a distance of more than 200 sentences.

Inter-sentence relation extraction deals with a number of complex semantic relationships in documents, which require local, non-local, syntactic and semantic dependencies. Existing methods do not fully exploit such dependencies. We present a novel inter-sentence relation extraction model that builds a labelled edge graph convolutional neural network model on a document-level graph. The graph is constructed using various inter- and intra-sentence dependencies to capture local and non-local dependency information. In order to predict the relation of an entity pair, we utilise multi-instance learning with bi-affine pairwise scoring. Experimental results show that our model achieves comparable performance to the state-of-the-art neural models on two biochemistry datasets. Our analysis shows that all the types in the graph are effective for inter-sentence relation extraction.

Existing biomedical coreference resolution systems depend on features and/or rules based on syntactic parsers. In this paper, we investigate the utility of the state-of-the-art general domain neural coreference resolution system on biomedical texts. The system is an end-to-end system without depending on any syntactic parsers. We also investigate the domain specific features to enhance the system for biomedical texts. Experimental results on the BioNLP Protein Coreference dataset and the CRAFT corpus show that, with no parser information, the adapted system compared favorably with the systems that depend on parser information on these datasets, achieving 51.23% on the BioNLP dataset and 36.33% on the CRAFT corpus in F1 score. In-domain embeddings and domain-specific features helped improve the performance on the BioNLP dataset, but they did not on the CRAFT corpus.

We present a novel graph-based neural network model for relation extraction. Our model treats multiple pairs in a sentence simultaneously and considers interactions among them. All the entities in a sentence are placed as nodes in a fully-connected graph structure. The edges are represented with position-aware contexts around the entity pairs. In order to consider different relation paths between two entities, we construct up to l-length walks between each pair. The resulting walks are merged and iteratively used to update the edge representations into longer walks representations. We show that the model achieves performance comparable to the state-of-the-art systems on the ACE 2005 dataset without using any external tools.

We propose a novel neural method to extract drug-drug interactions (DDIs) from texts using external drug molecular structure information. We encode textual drug pairs with convolutional neural networks and their molecular pairs with graph convolutional networks (GCNs), and then we concatenate the outputs of these two networks. In the experiments, we show that GCNs can predict DDIs from the molecular structures of drugs in high accuracy and the molecular information can enhance text-based DDI extraction by 2.39 percent points in the F-score on the DDIExtraction 2013 shared task data set.

Entity mentions embedded in longer entity mentions are referred to as nested entities. Most named entity recognition (NER) systems deal only with the flat entities and ignore the inner nested ones, which fails to capture finer-grained semantic information in underlying texts. To address this issue, we propose a novel neural model to identify nested entities by dynamically stacking flat NER layers. Each flat NER layer is based on the state-of-the-art flat NER model that captures sequential context representation with bidirectional Long Short-Term Memory (LSTM) layer and feeds it to the cascaded CRF layer. Our model merges the output of the LSTM layer in the current flat NER layer to build new representation for detected entities and subsequently feeds them into the next flat NER layer. This allows our model to extract outer entities by taking full advantage of information encoded in their corresponding inner entities, in an inside-to-outside way. Our model dynamically stacks the flat NER layers until no outer entities are extracted. Extensive evaluation shows that our dynamic model outperforms state-of-the-art feature-based systems on nested NER, achieving 74.7% and 72.2% on GENIA and ACE2005 datasets, respectively, in terms of F-score.

We propose a simple deep neural model for nested named entity recognition (NER). Most NER models focused on flat entities and ignored nested entities, which failed to fully capture underlying semantic information in texts. The key idea of our model is to enumerate all possible regions or spans as potential entity mentions and classify them with deep neural networks. To reduce the computational costs and capture the information of the contexts around the regions, the model represents the regions using the outputs of shared underlying bidirectional long short-term memory. We evaluate our exhaustive model on the GENIA and JNLPBA corpora in biomedical domain, and the results show that our model outperforms state-of-the-art models on nested and flat NER, achieving 77.1% and 78.4% respectively in terms of F-score, without any external knowledge resources.

We propose a novel embedding model that represents relationships among several elements in bibliographic information with high representation ability and flexibility. Based on this model, we present a novel search system that shows the relationships among the elements in the ACL Anthology Reference Corpus. The evaluation results show that our model can achieve a high prediction ability and produce reasonable search results.

We propose a novel attention mechanism for a Convolutional Neural Network (CNN)-based Drug-Drug Interaction (DDI) extraction model. CNNs have been shown to have a great potential on DDI extraction tasks; however, attention mechanisms, which emphasize important words in the sentence of a target-entity pair, have not been investigated with the CNNs despite the fact that attention mechanisms are shown to be effective for a general domain relation classification task. We evaluated our model on the Task 9.2 of the DDIExtraction-2013 shared task. As a result, our attention mechanism improved the performance of our base CNN-based DDI model, and the model achieved an F-score of 69.12%, which is competitive with the state-of-the-art models.

This paper tackles a problem of analyzing the well-formedness of syllables in Japanese Sign Language (JSL). We formulate the problem as a classification problem that classifies syllables into well-formed or ill-formed. We build a data set that contains hand-coded syllables and their well-formedness. We define a fine-grained feature set based on the hand-coded syllables and train a logistic regression classifier on labeled syllables, expecting to find the discriminative features from the trained classifier. We also perform pseudo active learning to investigate the applicability of active learning in analyzing syllables. In the experiments, the best classifier with our combinatorial features achieved the accuracy of 87.0%. The pseudo active learning is also shown to be effective showing that it could reduce about 84% of training instances to achieve the accuracy of 82.0% when compared to the model without active learning.

We propose a novel method that exploits visual information of ideograms and logograms in analyzing Japanese review documents. Our method first converts font images of Japanese characters into character embeddings using convolutional neural networks. It then constructs document embeddings from the character embeddings based on Hierarchical Attention Networks, which represent the documents based on attention mechanisms from a character level to a sentence level. The document embeddings are finally used to predict the labels of documents. Our method provides a way to exploit visual features of characters in languages with ideograms and logograms. In the experiments, our method achieved an accuracy comparable to a character embedding-based model while our method has much fewer parameters since it does not need to keep embeddings of thousands of characters.

This paper describes our TTI-COIN system that participated in SemEval-2017 Task 10. We investigated appropriate embeddings to adapt a neural end-to-end entity and relation extraction system LSTM-ER to this task. We participated in the full task setting of the entity segmentation, entity classification and relation classification (scenario 1) and the setting of relation classification only (scenario 3). The system was directly applied to the scenario 1 without modifying the codes thanks to its generality and flexibility. Our evaluation results show that the choice of appropriate pre-trained embeddings affected the performance significantly. With the best embeddings, our system was ranked third in the scenario 1 with the micro F1 score of 0.38. We also confirm that our system can produce the micro F1 score of 0.48 for the scenario 3 on the test data, and this score is close to the score of the 3rd ranked system in the task.

Classifying research grants into useful categories is a vital task for a funding body to give structure to the portfolio for analysis, informing strategic planning and decision-making. Automating this classification process would save time and effort, providing the accuracy of the classifications is maintained. We employ five classification models to classify a set of BBSRC-funded research grants in 21 research topics based on unigrams, technical terms and Latent Dirichlet Allocation models. To boost precision, we investigate methods for combining their predictions into five aggregate classifiers. Evaluation confirmed that ensemble classification models lead to higher precision.It was observed that there is not a single best-performing aggregate method for all research topics. Instead, the best-performing method for a research topic depends on the number of positive training instances available for this topic. Subject matter experts considered the predictions of aggregate models to correct erroneous or incomplete manual assignments.

We propose a novel word embedding-based hypernym generation model that jointly learns clusters of hyponym-hypernym relations, i.e., hypernymy, and projections from hyponym to hypernym embeddings. Most of the recent hypernym detection models focus on a hypernymy classification problem that determines whether a pair of words is in hypernymy or not. These models do not directly deal with a hypernym generation problem in that a model generates hypernyms for a given word. Differently from previous studies, our model jointly learns the clusters and projections with adjusting the number of clusters so that the number of clusters can be determined depending on the learned projections and vice versa. Our model also boosts the performance by incorporating inner product-based similarity measures and negative examples, i.e., sampled non-hypernyms, into our objectives in learning. We evaluated our joint learning models on the task of Japanese and English hypernym generation and showed a significant improvement over an existing pipeline model. Our model also compared favorably to existing distributed hypernym detection models on the English hypernym classification task.