User-generated data sources have gained significance in uncovering Adverse Drug Reactions (ADRs), with an increasing number of discussions occurring in the digital world. However, the existing clinical corpora predominantly revolve around scientific articles in English. This work presents a multilingual corpus of texts concerning ADRs gathered from diverse sources, including patient fora, social media, and clinical reports in German, French, and Japanese. Our corpus contains annotations covering 12 entity types, four attribute types, and 13 relation types. It contributes to the development of real-world multilingual language models for healthcare. We provide statistics to highlight certain challenges associated with the corpus and conduct preliminary experiments resulting in strong baselines for extracting entities and relations between these entities, both within and across languages.

Temporal relation annotation in the clinical domain is crucial yet challenging due to its workload and the medical expertise required. In this paper, we propose a novel annotation method that integrates event start-points ordering and question-answering (QA) as the annotation format. By focusing only on two points on a timeline, start-points ordering reduces ambiguity and simplifies the relation set to be considered during annotation. QA as annotation recasts temporal relation annotation into a reading comprehension task, allowing annotators to use natural language instead of the formalisms commonly adopted in temporal relation annotation. Based on our method, most of the relations in a document are inferable from a significantly smaller number of explicitly annotated relations, showing the efficiency of our proposed method. Using these inferred relations, we develop a temporal relation classification model that achieves a 0.72 F1 score. Also, by decomposing the annotation process into QA generation and QA validation, our method enables collaboration among medical experts and non-experts. We obtained high inter-annotator agreement (IAA) scores, which indicate the positive prospect of such collaboration in the annotation process. Our annotated corpus, annotation tool, and trained model are publicly available: https://github.com/seiji-shimizu/qa-start-ordering.

In medical and social media domains, annotated corpora are often hard to distribute due to copyrights and privacy issues. To overcome this situation, we propose a new method to generate a surrogate corpus for a downstream task by using a text generation model. We chose a medical multi-label classification task, MedWeb, in which patient-generated short messages express multiple symptoms. We first fine-tuned text generation models with different prompting designs on the original corpus to obtain synthetic versions of that corpus. To assess the viability of the generated corpora for the downstream task, we compared the performance of multi-label classification models trained either on the original or the surrogate corpora. The results and the error analysis showed the difficulty of generating surrogate corpus in multi-label settings, suggesting text generation under complex conditions is not trivial. On the other hand, our experiment demonstrates that the generated corpus with a sentinel-based prompting is comparatively viable in a single-label (multiclass) classification setting.

Since medical text cannot be shared easily due to privacy concerns, synthetic data bears much potential for natural language processing applications. In the context of social media and user-generated messages about drug intake and adverse drug effects, this work presents different methods to examine the authenticity of synthetic text. We conclude that the generated tweets are untraceable and show enough authenticity from the medical point of view to be used as a replacement for a real Twitter corpus. However, original data might still be the preferred choice as they contain much more diversity.

Entity Linking performance has a strong reliance on having a large quantity of high-quality annotated training data available. Yet, manual annotation of named entities, especially their boundaries, is ambiguous, error-prone, and raises many inconsistencies between annotators. While imprecise boundary annotation can degrade a model’s performance, there are applications where accurate extraction of entities’ surface form is not necessary. For those cases, a lenient annotation guideline could relieve the annotators’ workload and speed up the process. This paper presents a case study designed to verify the feasibility of such annotation process and evaluate the impact of boundary-relaxed annotation in an Entity Linking pipeline. We first generate a set of noisy versions of the widely used AIDA CoNLL-YAGO dataset by expanding the boundaries subsets of annotated entity mentions and then train three Entity Linking models on this data and evaluate the relative impact of imprecise annotation on entity recognition and disambiguation performances. We demonstrate that the magnitude of effects caused by noise in the Named Entity Recognition phase is dependent on both model complexity and noise ratio, while Entity Disambiguation components are susceptible to entity boundary imprecision due to strong vocabulary dependency.

Public opinion in social media is increasingly becoming a critical factor in pandemic control. Understanding the emotions of a population towards vaccinations and COVID-19 may be valuable in convincing members to become vaccinated. We investigated the emotions of Japanese Twitter users towards Tweets related to COVID-19 vaccination. Using the WRIME dataset, which provides emotion ratings for Japanese Tweets sourced from writers (Tweet posters) and readers, we fine-tuned a BERT model to predict levels of emotional intensity. This model achieved a training accuracy of MSE = 0.356. A separate dataset of 20,254 Japanese Tweets containing COVID-19 vaccine-related keywords was also collected, on which the fine-tuned BERT was used to perform emotion analysis. Afterwards, a correlation analysis between the extracted emotions and a set of vaccination measures in Japan was conducted.The results revealed that surprise and fear were the most intense emotions predicted by the model for writers and readers, respectively, on the vaccine-related Tweet dataset. The correlation analysis also showed that vaccinations were weakly positively correlated with predicted levels of writer joy, writer/reader anticipation, and writer/reader trust.

In the field of Japanese medical information extraction, few analyzing tools are available and relation extraction is still an under-explored topic. In this paper, we first propose a novel relation annotation schema for investigating the medical and temporal relations between medical entities in Japanese medical reports. We experiment with the practical annotation scenarios by separately annotating two different types of reports. We design a pipeline system with three components for recognizing medical entities, classifying entity modalities, and extracting relations. The empirical results show accurate analyzing performance and suggest the satisfactory annotation quality, the superiority of the latest contextual embedding models. and the feasible annotation strategy for high-accuracy demand.

Fake news provokes many societal problems; therefore, there has been extensive research on fake news detection tasks to counter it. Many fake news datasets were constructed as resources to facilitate this task. Contemporary research focuses almost exclusively on the factuality aspect of the news. However, this aspect alone is insufficient to explain “fake news,” which is a complex phenomenon that involves a wide range of issues. To fully understand the nature of each instance of fake news, it is important to observe it from various perspectives, such as the intention of the false news disseminator, the harmfulness of the news to our society, and the target of the news. We propose a novel annotation scheme with fine-grained labeling based on detailed investigations of existing fake news datasets to capture these various aspects of fake news. Using the annotation scheme, we construct and publish the first Japanese fake news dataset. The annotation scheme is expected to provide an in-depth understanding of fake news. We plan to build datasets for both Japanese and other languages using our scheme. Our Japanese dataset is published at https://hkefka385.github.io/dataset/fakenews-japanese/.

We present a publicly available corpus with detailed annotations describing the core elements of clinical trials: Participants, Intervention, Control, and Outcomes. The corpus consists of 1011 abstracts of breast cancer randomized controlled trials extracted from the PubMed database. The corpus improves previous corpora by providing detailed annotations for outcomes to identify numeric texts that report the number of participants that experience specific outcomes. The corpus will be helpful for the development of systems for automatic extraction of data from randomized controlled trial literature to support evidence-based medicine. Additionally, we demonstrate the feasibility of the corpus by using two strong baselines for named entity recognition task. Most of the entities achieve F1 scores greater than 0.80 demonstrating the quality of the dataset.

Fake news causes significant damage to society. To deal with these fake news, several studies on building detection models and arranging datasets have been conducted. Most of the fake news datasets depend on a specific time period. Consequently, the detection models trained on such a dataset have difficulty detecting novel fake news generated by political changes and social changes; they may possibly result in biased output from the input, including specific person names and organizational names. We refer to this problem as Diachronic Bias because it is caused by the creation date of news in each dataset. In this study, we confirm the bias, especially proper nouns including person names, from the deviation of phrase appearances in each dataset. Based on these findings, we propose masking methods using Wikidata to mitigate the influence of person names and validate whether they make fake news detection models robust through experiments with in-domain and out-of-domain data.

Disease name recognition and normalization is a fundamental process in biomedical text mining. Recently, neural joint learning of both tasks has been proposed to utilize the mutual benefits. While this approach achieves high performance, disease concepts that do not appear in the training dataset cannot be accurately predicted. This study introduces a novel end-to-end approach that combines span representations with dictionary-matching features to address this problem. Our model handles unseen concepts by referring to a dictionary while maintaining the performance of neural network-based models. Experiments using two major datasaets demonstrate that our model achieved competitive results with strong baselines, especially for unseen concepts during training.

Applying natural language processing (NLP) to medical and clinical texts can bring important social benefits by mining valuable information from unstructured text. A popular application for that purpose is named entity recognition (NER), but the annotation policies of existing clinical corpora have not been standardized across clinical texts of different types. This paper presents an annotation guideline aimed at covering medical documents of various types such as radiography interpretation reports and medical records. Furthermore, the annotation was designed to avoid burdensome requirements related to medical knowledge, thereby enabling corpus development without medical specialists. To achieve these design features, we specifically focus on critical lung diseases to stabilize linguistic patterns in corpora. After annotating around 1100 electronic medical records following the annotation scheme, we demonstrated its feasibility using an NER task. Results suggest that our guideline is applicable to large-scale clinical NLP projects.

This paper presents a prototype of a chat room that detects offensive expressions in a video live streaming chat in real time. Focusing on Twitch, one of the most popular live streaming platforms, we created a dataset for the task of detecting offensive expressions. We collected 2,000 chat posts across four popular game titles with genre diversity (e.g., competitive, violent, peaceful). To make use of the similarity in offensive expressions among different social media platforms, we adopted state-of-the-art models trained on offensive expressions from Twitter for our Twitch data (i.e., transfer learning). We investigated two similarity measurements to predict the transferability, textual similarity, and game-genre similarity. Our results show that the transfer of features from social media to live streaming is effective. However, the two measurements show less correlation in the transferability prediction.

We propose a data-to-text generation model with two modules, one for tracking and the other for text generation. Our tracking module selects and keeps track of salient information and memorizes which record has been mentioned. Our generation module generates a summary conditioned on the state of tracking module. Our proposed model is considered to simulate the human-like writing process that gradually selects the information by determining the intermediate variables while writing the summary. In addition, we also explore the effectiveness of the writer information for generations. Experimental results show that our proposed model outperforms existing models in all evaluation metrics even without writer information. Incorporating writer information further improves the performance, contributing to content planning and surface realization.

To date, various Twitter-based event detection systems have been proposed. Most of their targets, however, share common characteristics. They are seasonal or global events such as earthquakes and flu pandemics. In contrast, this study targets unseasonal and local disease events. Our system investigates the frequencies of disease-related words such as “nausea”,“chill”,and “diarrhea” and estimates the number of patients using regression of these word frequencies. Experiments conducted using Japanese 47 areas from January 2017 to April 2017 revealed that the detection of small and unseasonal event is extremely difficult (overall performance: 0.13). However, we found that the event scale and the detection performance show high correlation in the specified cases (in the phase of patient increasing or decreasing). The results also suggest that when 150 and more patients appear in a high population area, we can expect that our social sensors detect this outbreak. Based on these results, we can infer that social sensors can reliably detect unseasonal and local disease events under certain conditions, just as they can for seasonal or global events.

Due to the recent replacements of physical documents with electronic medical records (EMR), the importance of information processing in medical fields has been increased. We have been organizing the MedNLP task series in NTCIR-10 and 11. These workshops were the first shared tasks which attempt to evaluate technologies that retrieve important information from medical reports written in Japanese. In this report, we describe the NTCIR-12 MedNLPDoc task which is designed for more advanced and practical use for the medical fields. This task is considered as a multi-labeling task to a patient record. This report presents results of the shared task, discusses and illustrates remained issues in the medical natural language processing field.

In recent years, detecting Alzheimer disease (AD) in early stages based on natural language processing (NLP) has drawn much attention. To date, vocabulary size, grammatical complexity, and fluency have been studied using NLP metrics. However, the content analysis of AD narratives is still unreachable for NLP. This study investigates features of the words that AD patients use in their spoken language. After recruiting 18 examinees of 53–90 years old (mean: 76.89), they were divided into two groups based on MMSE scores. The AD group comprised 9 examinees with scores of 21 or lower. The healthy control group comprised 9 examinees with a score of 22 or higher. Linguistic Inquiry and Word Count (LIWC) classified words were used to categorize the words that the examinees used. The word frequency was found from observation. Significant differences were confirmed for the usage of impersonal pronouns in the AD group. This result demonstrated the basic feasibility of the proposed NLP-based detection approach.

Because of the increasing popularity of social media, much information has been shared on the internet, enabling social media users to understand various real world events. Particularly, social media-based infectious disease surveillance has attracted increasing attention. In this work, we specifically examine influenza: a common topic of communication on social media. The fundamental theory of this work is that several words, such as symptom words (fever, headache, etc.), appear in advance of flu epidemic occurrence. Consequently, past word occurrence can contribute to estimation of the number of current patients. To employ such forecasting words, one can first estimate the optimal time lag for each word based on their cross correlation. Then one can build a linear model consisting of word frequencies at different time points for nowcasting and for forecasting influenza epidemics. Experimentally obtained results (using 7.7 million tweets of August 2012 – January 2016), the proposed model achieved the best nowcasting performance to date (correlation ratio 0.93) and practically sufficient forecasting performance (correlation ratio 0.91 in 1-week future prediction, and correlation ratio 0.77 in 3-weeks future prediction). This report is the first of the relevant literature to describe a model enabling prediction of future epidemics using Twitter.

Example-based machine translation (EBMT) systems, so far, rely on heuristic measures in retrieving translation examples. Such a heuristic measure costs time to adjust, and might make its algorithm unclear. This paper presents a probabilistic model for EBMT. Under the proposed model, the system searches the translation example combination which has the highest probability. The proposed model clearly formalizes EBMT process. In addition, the model can naturally incorporate the context similarity of translation examples. The experimental results demonstrate that the proposed model has a slightly better translation quality than state-of-the-art EBMT systems.

This paper describes a system for finding phrasal translation correspondences from parallel parsed corpus that are collections paired English and Japanese sentences. First, the system finds phrasal correspondences by Japanese-English translation dictionary consultation. Then, the system finds correspondences in remaining phrases by using sentences dependency structures and the balance of all correspondences. The method is based on an assumption that in parallel corpus most fragments in a source sentence have corresponding fragments in a target sentence.