On Large Foundation Models and Alzheimer’s Disease Detection

Chuyuan Li, Giuseppe Carenini, Thalia Field


Abstract
Large Foundation Models have displayed incredible capabilities in a wide range of domains and tasks. However, it is unclear whether these models match specialist capabilities without special training or fine-tuning. In this paper, we investigate the innate ability of foundation models as neurodegenerative disease specialists. Precisely, we use a language model, Llama-3.1, and a visual language model, Llama3-LLaVA-NeXT, to detect language specificity between Alzheimer’s Disease patients and healthy controls through a well-known Picture Description task. Results show that Llama is comparable to supervised classifiers, while LLaVA, despite its additional “vision”, lags behind.
Anthology ID:
2025.cl4health-1.13
Volume:
Proceedings of the Second Workshop on Patient-Oriented Language Processing (CL4Health)
Month:
May
Year:
2025
Address:
Albuquerque, New Mexico
Editors:
Sophia Ananiadou, Dina Demner-Fushman, Deepak Gupta, Paul Thompson
Venues:
CL4Health | WS
SIG:
Publisher:
Association for Computational Linguistics
Note:
Pages:
158–168
Language:
URL:
https://preview.aclanthology.org/moar-dois/2025.cl4health-1.13/
DOI:
10.18653/v1/2025.cl4health-1.13
Bibkey:
Cite (ACL):
Chuyuan Li, Giuseppe Carenini, and Thalia Field. 2025. On Large Foundation Models and Alzheimer’s Disease Detection. In Proceedings of the Second Workshop on Patient-Oriented Language Processing (CL4Health), pages 158–168, Albuquerque, New Mexico. Association for Computational Linguistics.
Cite (Informal):
On Large Foundation Models and Alzheimer’s Disease Detection (Li et al., CL4Health 2025)
Copy Citation:
PDF:
https://preview.aclanthology.org/moar-dois/2025.cl4health-1.13.pdf