Large Language Models (LLMs) are vulnerable to jailbreak attacks that exploit weaknesses in traditional safety alignment, which often relies on rigid refusal heuristics or representation engineering to block harmful outputs. While they are effective for direct adversarial attacks, they fall short of broader safety challenges requiring nuanced, context-aware decision-making. To address this, we propose Reasoning-enhanced Fine-Tuning for interpretable LLM Safety (RATIONAL), a novel framework that trains models to engage in explicit safe reasoning before response. Fine-tuned models leverage the extensive pretraining knowledge in self-generated reasoning to bootstrap their own safety through structured reasoning, internalizing context-sensitive decision-making. Our findings suggest that safety extends beyond refusal, requiring context awareness for more robust, interpretable, and adaptive responses. Reasoning is not only a core capability of LLMs but also a fundamental mechanism for LLM safety. RATIONAL employs reasoning-enhanced fine-tuning, allowing it to reject harmful prompts while providing meaningful and context-aware responses in complex scenarios.

Large Language Models (LLMs) have demonstrated strong reasoning capabilities across various tasks. However, even minor variations in query phrasing, despite preserving the underlying semantic meaning, can significantly affect their performance. To address this, we focus on enhancing LLMs’ awareness of symmetry in query variations and propose syMmetry-ENhanceD (MEND) data augmentation, a data-centric approach that improves the model’s ability to extract useful information from context. Unlike existing methods that emphasize reasoning chain augmentation, our approach improves model robustness at the knowledge extraction stage through query augmentation, enabling more data-efficient training and stronger generalization to Out-of-Distribution (OOD) settings. Extensive experiments on both logical and arithmetic reasoning tasks show that MEND enhances reasoning performance across diverse query variations, providing new insights into improving LLM robustness through structured dataset curation.

What kind of basic research ideas are more likely to get applied in practice? There is a long line of research investigating patterns of knowledge transfer, but it generally focuses on documents as the unit of analysis and follow their transfer into practice for a specific scientific domain. Here we study translational research at the level of scientific concepts for all scientific fields. We do this through text mining and predictive modeling using three corpora: 38.6 million paper abstracts, 4 million patent documents, and 0.28 million clinical trials. We extract scientific concepts (i.e., phrases) from corpora as instantiations of “research ideas”, create concept-level features as motivated by literature, and then follow the trajectories of over 450,000 new concepts (emerged from 1995-2014) to identify factors that lead only a small proportion of these ideas to be used in inventions and drug trials. Results from our analysis suggest several mechanisms that distinguish which scientific concept will be adopted in practice, and which will not. We also demonstrate that our derived features can be used to explain and predict knowledge transfer with high accuracy. Our work provides greater understanding of knowledge transfer for researchers, practitioners, and government agencies interested in encouraging translational research.