Large language models (LLMs) have shown remarkable capabilities in general domains, but their application to multi-omics biology remains underexplored. To address this gap, we introduce Biology-Instructions, the first large-scale instruction-tuning dataset for multi-omics biological sequences, including DNA, RNA, proteins, and multi-molecules. This dataset bridges LLMs and complex biological sequence-related tasks, enhancing their versatility and reasoning while maintaining conversational fluency. We also highlight significant limitations of current state-of-the-art LLMs on multi-omics tasks without specialized training. To overcome this, we propose ChatMultiOmics, a strong baseline with a novel three-stage training pipeline, demonstrating superior biological understanding through Biology-Instructions. Both resources are publicly available, paving the way for better integration of LLMs in multi-omics analysis. The Biology-Instructions is publicly available at: https://github.com/hhnqqq/Biology-Instructions.

This paper presents LLaMA-Berry, an advanced mathematical reasoning framework to enhance the problem-solving ability of large language models (LLMs). The framework combines Monte Carlo Tree Search with Self-Refine (SR-MCTS) to optimize the reasoning paths and utilizes a pairwise reward model to evaluate different paths globally. By leveraging the self-critique and rewriting capabilities of LLMs, our SR-MCTS overcomes the inefficiencies and limitations of conventional step-wise and greedy search algorithms, enabling a more efficient exploration of solution spaces. To guide the search process, we propose the Pairwise Preference Reward Model (PPRM), which predicts pairwise preferences between solutions through instruction-following capabilities trained by Reinforcement Learning from Human Feedback (RLHF). Finally, the Enhanced Borda Count (EBC) method is adopted to synthesize pairwise preferences into global quantile scores for evaluations. This approach mitigates the challenges of scoring variability and non-independent distributions in mathematical reasoning tasks. The framework has been tested on general and advanced benchmarks, showing superior search efficiency and performance compared to existing open-source and closed-source methods, particularly in complex Olympiad-level benchmarks, including AIME24 and AMC23.