A novel literature-based discovery system based on UMLS Ontologies, Semantic Filters, Statistics, and Word Embed-dings was developed and validated against the well-established Raynaud’s disease – Fish Oil discovery by min-ing different size and specificity corpora of Pubmed titles and abstracts. Results show an ‘inverse effect’ between open ver-sus closed discovery search modes. In open discovery, a more general and bigger corpus (Vascular disease or Peri-vascular disease) produces better results than a more specific and smaller in size corpus (Raynaud disease), whereas in closed discovery, the exact opposite is true.