This paper described NiuTrans neural machine translation systems for the WMT 2019 news translation tasks. We participated in 13 translation directions, including 11 supervised tasks, namely EN↔{ZH, DE, RU, KK, LT}, GU→EN and the unsupervised DE↔CS sub-track. Our systems were built on Deep Transformer and several back-translation methods. Iterative knowledge distillation and ensemble+reranking were also employed to obtain stronger models. Our unsupervised submissions were based on NMT enhanced by SMT. As a result, we achieved the highest BLEU scores in {KK↔EN, GU→EN} directions, ranking 2nd in {RU→EN, DE↔CS} and 3rd in {ZH→EN, LT→EN, EN→RU, EN↔DE} among all constrained submissions.