Image Editing has made incredible progress in recent years. Earliest work only supported caption-guided editing. Recently, free-form text instructions and reference images are incorporated to allow more flexibility. However, existing methods still struggle with complicated editing instructions involving multiple objects or reference images. We present InstructAny2Pix, a novel image editing model that leverages a multi-modal LLM to execute complicated edit instructions. Compared with previous, works, InstructAny2Pix extends the flexibility of edit instructions in three ways: First, it can perform complex instructions involving multiple object edits; Second, it supports interleaving text instructions with multiple reference images; Third, it supports audio and music inputs as part of edit prompts, unlocking many creative applications, such as album cover generation and music-inspired merchandise design. To evaluate the effectiveness of InstructAny2Pix, we propose two new benchmark datasets MM-Inst and Dream-booth++ consisting of human written, multi-modal prompts. InstructAny2Pix outperforms baselines in these two proposed multi-modal benchmarks, as well as conventional image editing benchmarks such as InstructPix2Pix.