Despite growing interest in applying natural language processing (NLP) and computer vision (CV) models to the scholarly domain, scientific documents remain challenging to work with. They’re often in difficult-to-use PDF formats, and the ecosystem of models to process them is fragmented and incomplete. We introduce PaperMage, an open-source Python toolkit for analyzing and processing visually-rich, structured scientific documents. PaperMage offers clean and intuitive abstractions for seamlessly representing and manipulating both textual and visual document elements. PaperMage achieves this by integrating disparate state-of-the-art NLP and CV models into a unified framework, and provides turn-key recipes for common scientific document processing use-cases. PaperMage has powered multiple research prototypes of AI applications over scientific documents, along with Semantic Scholar’s large-scale production system for processing millions of PDFs. GitHub: https://github.com/allenai/papermage