Target Sense Verification (TSV) describes the binary disambiguation task of deciding whether the intended sense of a target word in a context corresponds to a given target sense. In this paper, we introduce WiC-TSV-de, a multi-domain dataset for German Target Sense Verification. While the training and development sets consist of domain-independent instances only, the test set contains domain-bound subsets, originating from four different domains, being Gastronomy, Medicine, Hunting, and Zoology. The domain-bound subsets incorporate adversarial examples such as in-domain ambiguous target senses and context-mixing (i.e., using the target sense in an out-of-domain context) which contribute to the challenging nature of the presented dataset. WiC-TSV-de allows for the development of sense-inventory-independent disambiguation models that can generalise their knowledge for different domain settings. By combining it with the original English WiC-TSV benchmark, we performed monolingual and cross-lingual analysis, where the evaluated baseline models were not able to solve the dataset to a satisfying degree, leaving a big gap to human performance.