Relation extraction (RE) is a well-known NLP application often treated as a sentence or document-level task. However, a handful of recent efforts explore it across documents or in the cross-document setting (CrossDocRE). This is distinct from the single document case because different documents often focus on disparate themes, while text within a document tends to have a single goal.Current CrossDocRE efforts do not consider domain knowledge, which are often assumed to be known to the reader when documents are authored. Here, we propose a novel approach, KXDocRE, that embed domain knowledge of entities with input text for cross-document RE. Our proposed framework has three main benefits over baselines: 1) it incorporates domain knowledge of entities along with documents’ text; 2) it offers interpretability by producing explanatory text for predicted relations between entities 3) it improves performance over the prior methods. Code and models are available at https://github.com/kracr/cross-doc-relation-extraction.