Previous studies of face-to-face (f2f) communication have suggested that speakers rely heavily on a variety of multi-modal cues to make real-time predictions about upcoming words in rapid turn-taking. To understand how computer-mediated communication (CMC) differs from f2f communication in terms of the prediction mechanism, this study assessed how the loss of multi-modal cues would affect word predictability in turn-taking. Participants watched videos, listened to audio, or read a transcript of f2f conversations. Across these three conditions, they predicted the same set of omitted words with different levels of predictability and semantic relatedness to other words in the context. Results showed that words of higher predictability were more accurately predicted regardless of CMC types. Higher response accuracy but longer response time were observed in conditions with richer cues, and for participants with more positive and less negative self-emotions. Meanwhile, semantic relatedness did not affect predictability. These results confirmed the key role of prediction in language processing and conversation smoothness, especially its importance in CMC.