We describe a data-driven approach for automatically explaining new, non-standard English expressions in a given sentence, building on a large dataset that includes 15 years of crowdsourced examples from UrbanDictionary.com. Unlike prior studies that focus on matching keywords from a slang dictionary, we investigate the possibility of learning a neural sequence-to-sequence model that generates explanations of unseen non-standard English expressions given context. We propose a dual encoder approach—a word-level encoder learns the representation of context, and a second character-level encoder to learn the hidden representation of the target non-standard expression. Our model can produce reasonable definitions of new non-standard English expressions given their context with certain confidence.