This paper delineates our investigation into the application of BioLinkBERT for enhancing clinical trials, presented at SemEval-2024 Task 2. Centering on the medical biomedical NLI task, our approach utilized the BioLinkBERT-large model, refined with a pioneering mixed loss function that amalgamates contrastive learning and cross-entropy loss. This methodology demonstrably surpassed the established benchmark, securing an impressive F1 score of 0.72 and positioning our work prominently in the field. Additionally, we conducted a comparative analysis of various deep learning architectures, including BERT, ALBERT, and XLM-RoBERTa, within the context of medical text mining. The findings not only showcase our method’s superior performance but also chart a course for future research in biomedical data processing. Our experiment source code is available on GitHub at: https://github.com/daojiaxu/semeval2024_task2.