Mixed Boolean-Arithmetic (MBA) obfuscation protects intellectual property by converting programs into forms that are more complex to analyze. However, MBA has been increasingly exploited by malware developers to evade detection and cause significant real-world problems. Traditional MBA deobfuscation methods often consider these expressions as part of a black box and overlook their internal semantic information. To bridge this gap, we propose a truth table, which is an automatically constructed semantic representation of an expression’s behavior that does not rely on external resources. The truth table is a mathematical form that represents the output of expression for all possible combinations of input. We also propose a general and extensible guided MBA deobfuscation framework (gMBA) that modifies a Transformer-based neural encoder-decoder Seq2Seq architecture to incorporate this semantic guidance. Experimental results and in-depth analysis show that integrating expression semantics significantly improves performance and highlights the importance of internal semantic expressions in recovering obfuscated code to its original form.