We provide a novel dataset – DiaWUG – with judgements on diatopic lexical semantic variation for six Spanish variants in Europe and Latin America. In contrast to most previous meaning-based resources and studies on semantic diatopic variation, we collect annotations on semantic relatedness for Spanish target words in their contexts from both a semasiological perspective (i.e., exploring the meanings of a word given its form, thus including polysemy) and an onomasiological perspective (i.e., exploring identical meanings of words with different forms, thus including synonymy). In addition, our novel dataset exploits and extends the existing framework DURel for annotating word senses in context (Erk et al., 2013; Schlechtweg et al., 2018) and the framework-embedded Word Usage Graphs (WUGs) – which up to now have mainly be used for semasiological tasks and resources – in order to distinguish, visualize and interpret lexical semantic variation of contextualized words in Spanish from these two perspectives, i.e., semasiological and onomasiological language variation.