Plain Language Summaries PLS improve health literacy and enable informed healthcare decisions but writing them requires domain expertise and is time-consuming. Automated methods often prioritize efficiency over comprehension and medical documents unique simplification requirements challenge generic solutions. We present a multi-agent system for generating PLS using Cochrane PLS as proof of concept. The system uses specialized agents for information extraction writing diagnosis and evaluation integrating a medical glossary and statistical analyzer to guide revisions. We evaluated three architectural configurations on 100 Cochrane abstracts using six LLMs both proprietary and open-source. Results reveal model-dependent trade-offs between factuality and readability with the multi-agent approach showing improvements for smaller models and providing operational advantages in control and interpretability.

We present an agent-based system for the TSAR 2025 Shared Task on Readability-Controlled Text Simplification, which requires simplifying English paragraphs from B2+ levels to target A2 or B1 levels while preserving meaning. Our approach employs specialized agents for keyword extraction, text generation, and evaluation, coordinated through an iterative refinement loop. The system integrates a CEFR vocabulary classifier, pretrained evaluation models, and few-shot learning from trial data. Through iterative feedback between the evaluator and writer agents, our system automatically refines outputs until they meet both readability and semantic preservation constraints. This architecture achieved 4th position among participating teams, showing the effectiveness of combining specialized LLMs with automated quality control strategies for text simplification.