Multi-session personalized dialogue generation is one of the most important topics in open-domain dialogue. It aims to generate responses consistent with the dialogue history and personality information across multiple sessions to engage users’ interest in the dialogue. Recent approaches focusing on history modeling and persona modeling have advanced the development of this field. However, they overlook the importance of dialogue structure in helping large language models (LLMs) understand the dialogue context. Moreover, these methods do not efficiently expand and utilize personality information, reducing the responses’ consistency. In this paper, we propose a Persona-Aware LLM-enAnCEd(PALACE) framework for multi-session personalized dialogue generation. Specifically, the framework consists of three components: a topic-aware memory bank, a persona prompt learning module, and VAE-LoRA. The topic-aware memory bank works by retrieving historical information that possesses a certain dialogue structure and relevant topics. The persona prompt learning module enhances the LLM’s persona-aware capabilities by utilizing a persona commonsense knowledge graph and a query-driven graph neural network. Furthermore, to enhance the generative capabilities of the LLM and obtain more useful prior knowledge, we combine VAE with LoRA to propose VAE-LoRA. Experimental results on the MSC and DuLeMon dataset demonstrate that our framework outperforms the state-of-the-art methods in automatic and human evaluation metrics.