Large Language Models (LLMs) have demonstrated impressive performance across various tasks. However, current training approaches combine standard cross-entropy loss with extensive data, human feedback, or ad hoc methods to enhance performance. These solutions are often not scalable or feasible due to their associated costs, complexity, or resource requirements. This study investigates the use of established semantic segmentation loss functions in natural language generation to create a versatile, practical, and scalable solution for fine-tuning different architectures. We evaluate their effectiveness in solving Math Word Problems and question answering across different models of varying sizes. For the analyzed tasks, we found that the traditional Cross-Entropy loss represents a sub-optimal choice, while models trained to minimize alternative (task-dependent) losses, such as Focal or Lovász, achieve a mean improvement of +36% on exact match without requiring additional data or human feedback. These findings suggest a promising pathway for more efficient and accessible training processes.