In this paper, we present OCTIS, a framework for training, analyzing, and comparing Topic Models, whose optimal hyper-parameters are estimated using a Bayesian Optimization approach. The proposed solution integrates several state-of-the-art topic models and evaluation metrics. These metrics can be targeted as objective by the underlying optimization procedure to determine the best hyper-parameter configuration. OCTIS allows researchers and practitioners to have a fair comparison between topic models of interest, using several benchmark datasets and well-known evaluation metrics, to integrate novel algorithms, and to have an interactive visualization of the results for understanding the behavior of each model. The code is available at the following link: https://github.com/MIND-Lab/OCTIS.