Zhuoyun Du


2025

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LLMs Can Simulate Standardized Patients via Agent Coevolution
Zhuoyun Du | LujieZheng LujieZheng | Renjun Hu | Yuyang Xu | Xiawei Li | Ying Sun | Wei Chen | Jian Wu | Haolei Cai | Haochao Ying
Proceedings of the 63rd Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers)

Training medical personnel using standardized patients (SPs) remains a complex challenge, requiring extensive domain expertise and role-specific practice. Most research on Large Language Model (LLM)-based simulated patients focuses on improving data retrieval accuracy or adjusting prompts through human feedback. However, this focus has overlooked the critical need for patient agents to learn a standardized presentation pattern that transforms data into human-like patient responses through unsupervised simulations. To address this gap, we propose EvoPatient, a novel simulated patient framework in which a patient agent and doctor agents simulate the diagnostic process through multi-turn dialogues, simultaneously gathering experience to improve the quality of both questions and answers, ultimately enabling human doctor training. Extensive experiments on various cases demonstrate that, by providing only overall SP requirements, our framework improves over existing reasoning methods by more than 10% in requirement alignment and better human preference, while achieving an optimal balance of resource consumption after evolving over 200 cases for 10 hours, with excellent generalizability. Our system will be available at https://github.com/ZJUMAI/EvoPatient

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Multi-Agent Collaboration via Cross-Team Orchestration
Zhuoyun Du | Chen Qian | Wei Liu | Zihao Xie | YiFei Wang | Rennai Qiu | Yufan Dang | Weize Chen | Cheng Yang | Ye Tian | Xuantang Xiong | Lei Han
Findings of the Association for Computational Linguistics: ACL 2025

Large Language Models (LLMs) have significantly impacted various domains, especially through organized LLM-driven autonomous agents. A representative scenario is in software development, where agents can collaborate in a team like humans, following predefined phases to complete sub-tasks sequentially. However, for an agent team, each phase yields only one possible outcome. This results in the completion of only one development chain, thereby losing the opportunity to explore multiple potential decision paths within the solution space. Consequently leading to suboptimal results or extensive trial and error. To address this, we introduce Cross-Team Orchestration (Croto), a scalable multi-team framework that enables orchestrated teams to jointly propose various task-oriented solutions and interact with their insights in a self-independence while cross-team collaboration environment for superior solutions generation. Experiments reveal a notable increase in software quality compared to state-of-the-art baselines. We further tested our framework on story generation tasks, which demonstrated a promising generalization ability of our framework in other domains. The code and data is available at https://github.com/OpenBMB/ChatDev/tree/macnet