Medical imaging provides essential visual insights for diagnosis, and multimodal large language models (MLLMs) are increasingly utilized for its analysis due to their strong generalization capabilities; however, the underlying factors driving this generalization remain unclear. Current research suggests that multi-task training outperforms single-task as different tasks can benefit each other, but they often overlook the internal relationships within these tasks. To analyze this phenomenon, we attempted to employ **compositional generalization** (CG), which refers to the models’ ability to understand novel combinations by recombining learned elements, as a guiding framework. Since medical images can be precisely defined by **M**odality, **A**natomical area, and **T**ask, naturally providing an environment for exploring CG, we assembled 106 medical datasets to create **Med-MAT** for comprehensive experiments. The experiments confirmed that MLLMs can use CG to understand unseen medical images and identified CG as one of the main drivers of the generalization observed in multi-task training. Additionally, further studies demonstrated that CG effectively supports datasets with limited data and confirmed that MLLMs can achieve CG across classification and detection tasks, underscoring its broader generalization potential. Med-MAT is available at https://github.com/FreedomIntelligence/Med-MAT.

Existing legal benchmarks focusing on knowledge and logic effectively evaluate LLMs on various tasks in legal domain. However, few have explored the practical application of LLMs by actual users. To further assess whether LLMs meet the specific needs of legal practitioners in real-world scenarios, we introduce UCL-Bench, a Chinese User-Centric Legal Benchmark, comprising 22 tasks across 5 distinct legal scenarios.To build the UCL-Bench, we conduct a user survey targeting legal professionals to understand their needs and challenges. Based on the survey results, we craft tasks, verified by legal professionals, and categorized them according to Bloom’s taxonomy. Each task in UCL-Bench mirrors real-world legal scenarios, and instead of relying on pre-defined answers, legal experts provide detailed answer guidance for each task, incorporating both “information” and “needs” elements to mimic the complexities of legal practice. With the guidance, we use GPT-4 as the user simulator and evaluator, enabling multi-turn dialogues as a answer guidance based evaluation framework. Our findings reveal that many recent open-source general models achieve the highest performance, suggesting that they are well-suited to address the needs of legal practitioners. However, these legal LLMs do not outperform ChatGPT, indicating a need for training strategies aligned with users’ needs. Furthermore, we find that the most effective models are able to address legal issues within fewer dialogue turns, highlighting the importance of concise and accurate responses in achieving high performance. The code and dataset are available at https://github.com/wittenberg11/UCL-bench.

The breakthrough of OpenAI o1 highlights the potential of enhancing reasoning to improve LLM. Yet, most research in reasoning has focused on mathematical tasks, leaving domains like medicine underexplored. The medical domain, though distinct from mathematics, also demands robust reasoning to provide reliable answers, given the high standards of healthcare. However, verifying medical reasoning is challenging, unlike those in mathematics. To address this, we propose **Medical Verifiable Problems** with a medical verifier to check the correctness of model outputs. This verifiable nature enables advancements in medical reasoning through **a two-stage approach**: (1) using the verifier to guide the search for a complex reasoning trajectory for fine-tuning LLMs, (2) applying reinforcement learning (RL) with verifier-based rewards to enhance complex reasoning further. Finally, we introduce HuatuoGPT-o1, a medical LLM capable of complex reasoning, which outperforms general and medical-specific baselines using only 40K verifiable problems. Experiments show complex reasoning improves medical problem-solving and benefits more from RL. We hope our approach inspires advancements in reasoning across medical and other specialized domains. Code, datasets, and models are publicly available at https://github.com/FreedomIntelligence/HuatuoGPT-o1.

The rapid development of multimodal large language models (MLLMs), such as GPT-4V, has led to significant advancements. However, these models still face challenges in medical multimodal capabilities due to limitations in the quantity and quality of medical vision-text data, stemming from data privacy concerns and high annotation costs. While pioneering approaches utilize PubMed’s large-scale, de-identified medical image-text pairs to address these limitations, they often fall short due to inherent data noise. To tackle this, we refined medical image-text pairs from PubMed and employed MLLMs (GPT-4V) in an ‘unblinded’ capacity to denoise and reformat the data, resulting in the creation of the **PubMedVision** dataset with 1.3 million medical VQA samples. Our validation demonstrates that: (1) PubMedVision can significantly enhance the medical multimodal capabilities of MLLMs, showing significant improvement in benchmarks including the MMMU Health & Medicine track; (2) manual checks by medical experts and empirical results validate the superior data quality of our dataset compared to other data construction methods. Using PubMedVision, we train a 34B medical MLLM **HuatuoGPT-Vision**, which shows superior performance in medical multimodal scenarios among open-source MLLMs. Our code and data are available at https://github.com/FreedomIntelligence/HuatuoGPT-Vision.