Protein language models have emerged as powerful tools for sequence generation, offering substantial advantages in functional optimization and *denovo* design. However, these models also present significant risks of generating harmful protein sequences, such as those that enhance viral transmissibility or evade immune responses. These concerns underscore critical biosafety and ethical challenges. To address these issues, we propose a Knowledge-guided Preference Optimization (KPO) framework that integrates prior knowledge via a Protein Safety Knowledge Graph. This framework utilizes an efficient graph pruning strategy to identify preferred sequences and employs reinforcement learning to minimize the risk of generating harmful proteins. Experimental results demonstrate that KPO effectively reduces the likelihood of producing hazardous sequences while maintaining high functionality, offering a robust safety assurance framework for applying generative models in biotechnology.

Large language models (LLMs) are trained on extensive historical corpora, but their ability to understand time and maintain temporal awareness of time-evolving factual knowledge remains limited. Previous studies often neglect the critical aspect of utilizing knowledge from various sources. To address this gap, we introduce EvolveBench, a comprehensive benchmark that evaluates temporal competence along five key dimensions: Cognition, which examines the ability to recall and contextualize historical facts. Awareness, which tests LLMs’ awareness of temporal misalignment between external inputs and the temporal context of a query. Trustworthiness, which assesses whether models can identify and appropriately refuse queries based on invalid timestamps. Understanding, which focuses on interpreting both explicit dates and implicit historical markers. Finally, reasoning evaluates the capacity to analyze temporal relationships and draw accurate inferences. Evaluating 15 widely used LLMs on EvolveBench shows that GPT-4o achieves the highest average EM score of 79.36, while the open-source Llama3.1-70B demonstrates notable strength in handling temporally misaligned contexts with an average score of 72.47. Despite these advances, all models still struggle with handling temporal misaligned context. Our code and dataset are available at https://github.com/zzysjtuiwct/EvolveBench.

The lack of training data gives rise to the system cold-start problem in recommendation systems, making them struggle to provide effective recommendations. To address this problem, Large Language Models(LLMs) can model recommendation tasks as language analysis tasks and provide zero-shot results based on their vast open-world knowledge. However, the large scale of the item corpus poses a challenge to LLMs, leading to substantial token consumption that makes it impractical to deploy in real-world recommendation systems. To tackle this challenge, we introduce a tree-based LLM recommendation framework LLMTreeRec, which structures all items into an item tree to improve the efficiency of LLM’s item retrieval. LLMTreeRec achieves state-of-the-art performance under the system cold-start setting in two widely used datasets, which is even competitive with conventional deep recommendation systems that use substantial training data. Furthermore, LLMTreeRec outperforms the baseline model in the A/B test on Huawei industrial system. Consequently, LLMTreeRec demonstrates its effectiveness as an industry-friendly solution that has been successfully deployed online.

Large language models (LLMs) have shown impressive prowess in solving a wide range of tasks with world knowledge. However, it remains unclear how well LLMs are able to perceive their factual knowledge boundaries, particularly under retrieval augmentation settings. In this study, we present the first analysis on the factual knowledge boundaries of LLMs and how retrieval augmentation affects LLMs on open-domain question answering (QA), with a bunch of important findings. Specifically, we focus on three research questions and analyze them by examining QA, priori judgement and posteriori judgement capabilities of LLMs. We show evidence that LLMs possess unwavering confidence in their knowledge and cannot handle the conflict between internal and external knowledge well. Furthermore, retrieval augmentation proves to be an effective approach in enhancing LLMs’ awareness of knowledge boundaries. We further conduct thorough experiments to examine how different factors affect LLMs and propose a simple method to dynamically utilize supporting documents with our judgement strategy. Additionally, we find that the relevance between the supporting documents and the questions significantly impacts LLMs’ QA and judgemental capabilities.

The reranker and generator are two critical components in the Retrieval-Augmented Generation (i.e., RAG) pipeline, responsible for ranking relevant documents and generating responses. However, due to differences in pre-training data and objectives, there is an inevitable gap between the documents ranked as relevant by the reranker and those required by the generator to support answering the query. To address this gap, we propose RADIO, a novel and practical preference alignment framework with RAtionale DIstillatiOn. Specifically, We first propose a rationale extraction method that leverages the reasoning capabilities of large language models (LLMs) to extract the rationales necessary for answering the query. Subsequently, a rationale-based alignment process is designed to rerank the documents based on the extracted rationales, and fine-tune the reranker to align the preferences. We conduct extensive experiments on two tasks across three datasets to demonstrate the effectiveness of our approach compared to baseline methods. Our code is released online to ease reproduction.

Power consumption plays a crucial role in on-device streaming speech recognition, significantly influencing the user experience. This study explores how the configuration of weight parameters in speech recognition models affects their overall energy efficiency. We found that the influence of these parameters on power consumption varies depending on factors such as invocation frequency and memory allocation. Leveraging these insights, we propose design principles that enhance on-device speech recognition models by reducing power consumption with minimal impact on accuracy. Our approach, which adjusts model components based on their specific energy sensitivities, achieves up to 47% lower energy usage while preserving comparable model accuracy and improving real-time performance compared to leading methods.

Recent advancements in Multimodal Large Language Models (MLLMs) have demonstrated exceptional capabilities in visual perception and understanding. However, these models also suffer from hallucinations, which limit their reliability as AI systems. We believe that these hallucinations are partially due to the models’ struggle with understanding what they can and cannot perceive from images, a capability we refer to as self-awareness in perception. Despite its importance, this aspect of MLLMs has been overlooked in prior studies. In this paper, we aim to define and evaluate the self-awareness of MLLMs in perception. To do this, we first introduce the knowledge quadrant in perception, which helps define what MLLMs know and do not know about images. Using this framework, we propose a novel benchmark, the Self-Awareness in Perception for MLLMs (MM-SAP), specifically designed to assess this capability. We apply MM-SAP to a variety of popular MLLMs, offering a comprehensive analysis of their self-awareness and providing detailed insights. The experiment results reveal that current MLLMs possess limited self-awareness capabilities, pointing to a crucial area for future advancement in the development of trustworthy MLLMs. Code and data are available at https://github.com/YHWmz/MM-SAP.

To facilitate the research on large language models (LLMs), this paper presents a comprehensive and unified library, LLMBox, to ease the development, use, and evaluation of LLMs. This library is featured with three main merits: (1) a unified data interface that supports the flexible implementation of various training strategies, (2) a comprehensive evaluation that covers extensive tasks, datasets, and models, and (3) more practical consideration, especially on user-friendliness and efficiency. With our library, users can easily reproduce existing methods, train new models, and conduct comprehensive performance comparisons. To rigorously test LLMBox, we conduct extensive experiments in a diverse coverage of evaluation settings, and experimental results demonstrate the effectiveness and efficiency of our library in supporting various implementations related to LLMs. The detailed introduction and usage guidance can be found at https://github.com/RUCAIBox/LLMBox.

Considering the limited internal parametric knowledge, retrieval-augmented generation (RAG) has been widely used to extend the knowledge scope of large language models (LLMs). Despite the extensive efforts on RAG research, in existing methods, LLMs cannot precisely assess the relevance of retrieved documents, thus likely leading to misleading or even incorrect utilization of external knowledge (i.e., retrieved documents). To address this issue, in this paper, we propose REAR, a RElevance-Aware Retrieval-augmented approach for open-domain question answering (QA). As the key motivation, we aim to enhance the self-awareness regarding the reliability of external knowledge for LLMs, so as to adaptively utilize external knowledge in RAG systems. Specially, we develop a novel architecture for LLM based RAG system, by incorporating a specially designed assessnent module that precisely assesses the relevance of retrieved documents. Furthermore, we propose an improved training method based on bi-granularity relevance fusion and noise-resistant training. By combining the improvements in both architecture and training, our proposed REAR can better utilize external knowledge by effectively perceiving the relevance of retrieved documents. Experiments on four open-domain QA tasks show that REAR significantly outperforms previous a number of competitive RAG approaches. Our codes can be accessed at https://github.com/RUCAIBox/REAR.