Natural Language Processing in Support of Evidence-based Medicine: A Scoping Review

Zihan Xu, Haotian Ma, Yihao Ding, Gongbo Zhang, Chunhua Weng, Yifan Peng


Abstract
Evidence-based medicine (EBM) is at the forefront of modern healthcare, emphasizing the use of the best available scientific evidence to guide clinical decisions. Due to the sheer volume and rapid growth of medical literature and the high cost of curation, there is a critical need to investigate Natural Language Processing (NLP) methods to identify, appraise, synthesize, summarize, and disseminate evidence in EBM. This survey presents an in-depth review of 129 research studies on leveraging NLP for EBM, illustrating its pivotal role in enhancing clinical decision-making processes. The paper systematically explores how NLP supports the five fundamental steps of EBM—Ask, Acquire, Appraise, Apply, and Assess. The review not only identifies current limitations within the field but also proposes directions for future research, emphasizing the potential for NLP to revolutionize EBM by refining evidence extraction, evidence synthesis, appraisal, summarization, enhancing data comprehensibility, and facilitating a more efficient clinical workflow.
Anthology ID:
2025.findings-acl.1103
Volume:
Findings of the Association for Computational Linguistics: ACL 2025
Month:
July
Year:
2025
Address:
Vienna, Austria
Editors:
Wanxiang Che, Joyce Nabende, Ekaterina Shutova, Mohammad Taher Pilehvar
Venue:
Findings
SIG:
Publisher:
Association for Computational Linguistics
Note:
Pages:
21421–21443
Language:
URL:
https://preview.aclanthology.org/landing_page/2025.findings-acl.1103/
DOI:
Bibkey:
Cite (ACL):
Zihan Xu, Haotian Ma, Yihao Ding, Gongbo Zhang, Chunhua Weng, and Yifan Peng. 2025. Natural Language Processing in Support of Evidence-based Medicine: A Scoping Review. In Findings of the Association for Computational Linguistics: ACL 2025, pages 21421–21443, Vienna, Austria. Association for Computational Linguistics.
Cite (Informal):
Natural Language Processing in Support of Evidence-based Medicine: A Scoping Review (Xu et al., Findings 2025)
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PDF:
https://preview.aclanthology.org/landing_page/2025.findings-acl.1103.pdf