Discriminative pre-trained language models, such as ELECTRA, have achieved promising performances in a variety of general tasks. However, these generic pre-trained models struggle to capture domain-specific knowledge of domain-related tasks. In this work, we propose a novel domain-adaptation method for ELECTRA, which can dynamically select domain-specific tokens and guide the discriminator to emphasize them, without introducing new training parameters. We show that by re-weighting the losses of domain-specific tokens, ELECTRA can be effectively adapted to different domains. The experimental results in both computer science and biomedical domains show that the proposed method can achieve state-of-the-art results on the domain-related tasks.