Quality estimation (QE) is a crucial method to investigate automatic methods for estimating the quality of machine translation results without reference translations. This paper presents Huawei Translation Services Center’s (HW-TSC’s) work called CrossQE in WMT 2022 QE shared tasks 1 and 2, namely sentence- and word- level quality prediction and explainable QE.CrossQE employes the framework of predictor-estimator for task 1, concretely with a pre-trained cross-lingual XLM-RoBERTa large as predictor and task-specific classifier or regressor as estimator. An extensive set of experimental results show that after adding bottleneck adapter layer, mean teacher loss, masked language modeling task loss and MC dropout methods in CrossQE, the performance has improved to a certain extent. For task 2, CrossQE calculated the cosine similarity between each word feature in the target and each word feature in the source by task 1 sentence-level QE system’s predictor, and used the inverse value of maximum similarity between each word in the target and the source as the word translation error risk value. Moreover, CrossQE has outstanding performance on QE test sets of WMT 2022.