Supervised training of existing deep learning models for sequence labeling relies on large scale labeled datasets. Such datasets are generally created with crowd-source labeling. However, crowd-source labeling for tasks of sequence labeling can be expensive and time-consuming. Further, crowd-source labeling by external annotators may not be appropriate for data that contains user private information. Considering the above limitations of crowd-source labeling, we study interactive sequence labeling that allows training directly with the user feedback, which alleviates the annotation cost and maintains the user privacy. We identify two bias, namely, context bias and feedback bias, by formulating interactive sequence labeling via a Structural Causal Model (SCM). To alleviate the context and feedback bias based on the SCM, we identify the frequent context tokens as confounders in the backdoor adjustment and further propose an entropy-based modulation that is inspired by information theory. entities more sample-efficiently. With extensive experiments, we validate that our approach can effectively alleviate the biases and our models can be efficiently learnt with the user feedback.