Recent advancements in Large Vision Language Models (LVLMs) show promise for pathological diagnosis, yet their application in clinical settings faces critical challenges of multimodal hallucination and biased responses. While preference alignment methods have proven effective in general domains, acquiring high-quality preference data for pathology remains challenging due to limited expert resources and domain complexity. In this paper, we propose EAGLE (Expert-guided self-enhancement for preference Alignment in patholoGy Large vision-languagE model), a novel framework that systematically integrates medical expertise into preference alignment. EAGLE consists of three key stages: initialization through supervised fine-tuning, self-preference creation leveraging expert prompting and medical entity recognition, and iterative preference following-tuning. The self-preference creation stage uniquely combines expert-verified chosen sampling with expert-guided rejected sampling to generate high-quality preference data, while the iterative tuning process continuously refines both data quality and model performance. Extensive experiments demonstrate that EAGLE significantly outperforms existing pathological LVLMs, effectively reducing hallucination and bias while maintaining pathological accuracy. The source code is available at https://github.com/meidandz/EAGLE.

The significant breakthroughs of Medical Multi-Modal Large Language Models (Med-MLLMs) renovate modern healthcare with robust information synthesis and medical decision support. However, these models are often evaluated on benchmarks that are unsuitable for the Med-MLLMs due to the intricate nature of the real-world diagnostic frameworks, which encompass diverse medical specialties and involve complex clinical decisions. Thus, a clinically representative benchmark is highly desirable for credible Med-MLLMs evaluation. To this end, we introduce Asclepius, a novel Med-MLLM benchmark that comprehensively assesses Med-MLLMs in terms of: distinct medical specialties (cardiovascular, gastroenterology, etc.) and different diagnostic capacities (perception, disease analysis, etc.). Grounded in 3 proposed core principles, Asclepius ensures a comprehensive evaluation by encompassing 15 medical specialties, stratifying into 3 main categories and 8 sub-categories of clinical tasks, and exempting overlap with the existing VQA dataset. We further provide an in-depth analysis of 6 Med-MLLMs and compare them with 3 human specialists, providing insights into their competencies and limitations in various medical contexts. Our work not only advances the understanding of Med-MLLMs’ capabilities but also sets a precedent for future evaluations and the safe deployment of these models in clinical environments.

Fine-grained vision-language models (VLM) have been widely used for inter-modality local alignment between the predefined fixed patches and textual words. However, in medical analysis, lesions exhibit varying sizes and positions, and using fixed patches may cause incomplete representations of lesions. Moreover, these methods provide explainability by using heatmaps to show the general image areas potentially associated with texts rather than specific regions, making their explanations not explicit and specific enough. To address these issues, we propose a novel Adaptive patch-word Matching (AdaMatch) model to correlate chest X-ray (CXR) image regions with words in medical reports and apply it to CXR-report generation to provide explainability for the generation process. AdaMatch exploits the fine-grained relation between adaptive patches and words to provide explanations of specific image regions with corresponding words. To capture the abnormal regions of varying sizes and positions, we introduce an Adaptive Patch extraction (AdaPatch) module to acquire adaptive patches for these regions adaptively. Aiming to provide explicit explainability for the CXR-report generation task, we propose an AdaMatch-based bidirectional LLM for Cyclic CXR-report generation (AdaMatch-Cyclic). It employs AdaMatch to obtain the keywords for CXR images and ‘keypatches’ for medical reports as hints to guide CXR-report generation. Extensive experiments on two publicly available CXR datasets validate the effectiveness of our method and its superior performance over existing methods. Source code will be released.

Recently, the success of pre-training in text domain has been fully extended to vision, audio, and cross-modal scenarios. The proposed pre-training models of different modalities are showing a rising trend of homogeneity in their model structures, which brings the opportunity to implement different pre-training models within a uniform framework. In this paper, we present TencentPretrain, a toolkit supporting pre-training models of different modalities. The core feature of TencentPretrain is the modular design. The toolkit uniformly divides pre-training models into 5 components: embedding, encoder, target embedding, decoder, and target. As almost all of common modules are provided in each component, users can choose the desired modules from different components to build a complete pre-training model. The modular design enables users to efficiently reproduce existing pre-training models or build brand-new one. We test the toolkit on text, vision, and audio benchmarks and show that it can match the performance of the original implementations.

Scientific literature serves as a high-quality corpus, supporting a lot of Natural Language Processing (NLP) research. However, existing datasets are centered around the English language, which restricts the development of Chinese scientific NLP. In this work, we present CSL, a large-scale Chinese Scientific Literature dataset, which contains the titles, abstracts, keywords and academic fields of 396k papers. To our knowledge, CSL is the first scientific document dataset in Chinese. The CSL can serve as a Chinese corpus. Also, this semi-structured data is a natural annotation that can constitute many supervised NLP tasks. Based on CSL, we present a benchmark to evaluate the performance of models across scientific domain tasks, i.e., summarization, keyword generation and text classification. We analyze the behavior of existing text-to-text models on the evaluation tasks and reveal the challenges for Chinese scientific NLP tasks, which provides a valuable reference for future research. Data and code will be publicly available.