Role-playing enables large language models (LLMs) to engage users in immersive and personalized interactions, but it also introduces significant safety risks. Existing role-play fine-tuning techniques improve role adaptability but may degrade safety performance, particularly for villainous characters. In this work, we conduct the first comprehensive assessment of role-play fine-tuning risks by training 95 role-specific LLMs using RoleBench. Our experiments reveal that role-play fine-tuning leads to a noticeable decline in safety performance, with safety risks varying based on character traits. To tackle this challenge, we propose Safety-Aware Role-Play Fine-Tuning (SaRFT), a novel method designed to balance role-playing capabilities and safety. Extensive experiments on LLaMA-3-8B-Instruct, Gemma-2-9B-it, and Qwen2.5-7B-Instruct demonstrate that SaRFT consistently outperforms state-of-the-art baselines under both LoRA and full-parameter fine-tuning settings. Our findings highlight the necessity of role-adaptive safety measures and provide insights into mitigating role-specific safety risks in role-playing LLMs.

This work explores sequential model editing in large language models (LLMs), a critical task that involves modifying internal knowledge within LLMs continuously through multi-round editing, each incorporating updates or corrections to adjust the model’s outputs without the need for costly retraining. Existing model editing methods, especially those that alter model parameters, typically focus on single-round editing and often face significant challenges in sequential model editing-most notably issues of model forgetting and failure. To address these challenges, we introduce a new model editing method, namely Neuron-level Sequential Editing (NSE), tailored for supporting sequential model editing. Specifically, we optimize the target layer’s hidden states using the model’s original weights to prevent model failure. Furthermore, we iteratively select neurons in multiple layers for editing based on their activation values to mitigate model forgetting. Our empirical experiments demonstrate that NSE significantly outperforms current modifying parameters model editing methods, marking a substantial advancement in the field of sequential model editing. Our code is released on https://anonymous.4open.science/r/NSE-0A8D/.

Large language models (LLMs) have become increasingly central to AI applications worldwide, necessitating robust multilingual safety alignment to ensure secure deployment across diverse linguistic contexts. Existing preference learning methods for safety alignment, such as RLHF and DPO, are primarily monolingual and struggle with noisy multilingual data. To address these limitations, we introduce Multilingual reward gaP Optimization (MPO), a novel approach that leverages the well-aligned safety capabilities of the dominant language (e.g., English) to improve safety alignment across multiple languages. MPO directly minimizes the reward gap difference between the dominant language and target languages, effectively transferring safety capabilities while preserving the original strengths of the dominant language. Extensive experiments on three LLMs, LLaMA-3.1, Gemma-2 and Qwen2.5, validate MPO’s efficacy in multilingual safety alignment without degrading general multilingual utility.

Open-domain dialogue systems have seen remarkable advancements with the development of large language models (LLMs). Nonetheless, most existing dialogue systems predominantly focus on brief single-session interactions, neglecting the real-world demands for long-term companionship and personalized interactions with chatbots. Crucial to addressing this real-world need are event summary and persona management, which enable reasoning for appropriate long-term dialogue responses. Recent progress in the human-like cognitive and reasoning capabilities of LLMs suggests that LLM-based agents could significantly enhance automated perception, decision-making, and problem-solving. In response to this potential, we introduce a model-agnostic framework, the Long-term Dialogue Agent (LD-Agent), which incorporates three independently tunable modules dedicated to event perception, persona extraction, and response generation. For the event memory module, long and short-term memory banks are employed to separately focus on historical and ongoing sessions, while a topic-based retrieval mechanism is introduced to enhance the accuracy of memory retrieval. Furthermore, the persona module conducts dynamic persona modeling for both users and agents. The integration of retrieved memories and extracted personas is subsequently fed into the generator to induce appropriate responses. The effectiveness, generality, and cross-domain capabilities of LD-Agent are empirically demonstrated across various illustrative benchmarks, models, and tasks. The code is released at https://github.com/leolee99/LD-Agent.

Language Models (LMs) excel in understanding textual descriptions of proteins, as evident in biomedical question-answering tasks. However, their capability falters with raw protein data, such as amino acid sequences, due to a deficit in pretraining on such data. Conversely, Protein Language Models (PLMs) can understand and convert protein data into high-quality representations, but struggle to process texts. To address their limitations, we introduce ProtT3, a framework for Protein-to-Text Generation for Text-based Protein Understanding. ProtT3 empowers an LM to understand protein sequences of amino acids by incorporating a PLM as its protein understanding module, enabling effective protein-to-text generation. This collaboration between PLM and LM is facilitated by a cross-modal projector (i.e., Q-Former) that bridges the modality gap between the PLM’s representation space and the LM’s input space. Unlike previous studies focusing on protein property prediction and protein-text retrieval, we delve into the largely unexplored field of protein-to-text generation. To facilitate comprehensive benchmarks and promote future research, we establish quantitative evaluations for protein-text modeling tasks, including protein captioning, protein question-answering, and protein-text retrieval. Our experiments show that ProtT3 substantially surpasses current baselines, with ablation studies further highlighting the efficacy of its core components. Our code is available at https://github.com/acharkq/ProtT3.

Molecule-text modeling, which aims to facilitate molecule-relevant tasks with a textual interface and textual knowledge, is an emerging research direction. Beyond single molecules, studying reaction-text modeling holds promise for helping the synthesis of new materials and drugs. However, previous works mostly neglect reaction-text modeling: they primarily focus on modeling individual molecule-text pairs or learning chemical reactions without texts in context. Additionally, one key task of reaction-text modeling – experimental procedure prediction – is less explored due to the absence of an open-source dataset. The task is to predict step-by-step actions of conducting chemical experiments and is crucial to automating chemical synthesis. To resolve the challenges above, we propose a new pretraining method, ReactXT, for reaction-text modeling, and a new dataset, OpenExp, for experimental procedure prediction. Specifically, ReactXT features three types of input contexts to incrementally pretrain LMs. Each of the three input contexts corresponds to a pretraining task to improve the text-based understanding of either reactions or single molecules. ReactXT demonstrates consistent improvements in experimental procedure prediction and molecule captioning and offers competitive results in retrosynthesis. Our code is available at https://github.com/syr-cn/ReactXT.

Predicting chemical reactions, a fundamental challenge in chemistry, involves forecasting the resulting products from a given reaction process. Conventional techniques, notably those employing Graph Neural Networks (GNNs), are often limited by insufficient training data and their inability to utilize textual information, undermining their applicability in real-world applications. In this work, we propose **ReLM**, a novel framework that leverages the chemical knowledge encoded in language models (LMs) to assist GNNs, thereby enhancing the accuracy of real-world chemical reaction predictions. To further enhance the model’s robustness and interpretability, we incorporate the confidence score strategy, enabling the LMs to self-assess the reliability of their predictions. Our experimental results demonstrate that ReLM improves the performance of state-of-the-art GNN-based methods across various chemical reaction datasets, especially in out-of-distribution settings. Codes are available at https://github.com/syr-cn/ReLM.