Medical Graph RAG: Evidence-based Medical Large Language Model via Graph Retrieval-Augmented Generation
Junde Wu, Jiayuan Zhu, Yunli Qi, Jingkun Chen, Min Xu, Filippo Menolascina, Yueming Jin, Vicente Grau
Abstract
We introduce MedGraphRAG, a novel graph-based Retrieval-Augmented Generation (RAG) framework designed to enhance LLMs in generating evidence-based medical responses, improving safety and reliability with private medical data. We introduce Triple Graph Construction and U-Retrieval to enhance GraphRAG, enabling holistic insights and evidence-based response generation for medical applications. Specifically, we connect user documents to credible medical sources and integrate Top-down Precise Retrieval with Bottom-up Response Refinement for balanced context awareness and precise indexing. Validated on 9 medical Q&A benchmarks, 2 health fact-checking datasets, and a long-form generation test set, MedGraphRAG outperforms state-of-the-art models while ensuring credible sourcing. Our code is publicly available.- Anthology ID:
- 2025.acl-long.1381
- Volume:
- Proceedings of the 63rd Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers)
- Month:
- July
- Year:
- 2025
- Address:
- Vienna, Austria
- Editors:
- Wanxiang Che, Joyce Nabende, Ekaterina Shutova, Mohammad Taher Pilehvar
- Venue:
- ACL
- SIG:
- Publisher:
- Association for Computational Linguistics
- Note:
- Pages:
- 28443–28467
- Language:
- URL:
- https://preview.aclanthology.org/ingestion-acl-25/2025.acl-long.1381/
- DOI:
- Cite (ACL):
- Junde Wu, Jiayuan Zhu, Yunli Qi, Jingkun Chen, Min Xu, Filippo Menolascina, Yueming Jin, and Vicente Grau. 2025. Medical Graph RAG: Evidence-based Medical Large Language Model via Graph Retrieval-Augmented Generation. In Proceedings of the 63rd Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers), pages 28443–28467, Vienna, Austria. Association for Computational Linguistics.
- Cite (Informal):
- Medical Graph RAG: Evidence-based Medical Large Language Model via Graph Retrieval-Augmented Generation (Wu et al., ACL 2025)
- PDF:
- https://preview.aclanthology.org/ingestion-acl-25/2025.acl-long.1381.pdf