VenusFactory: An Integrated System for Protein Engineering with Data Retrieval and Language Model Fine-Tuning
Yang Tan, Chen Liu, Jingyuan Gao, Wu Banghao, Mingchen Li, Ruilin Wang, Lingrong Zhang, Huiqun Yu, Guisheng Fan, Liang Hong, Bingxin Zhou
Abstract
Natural language processing (NLP) has significantly influenced scientific domains beyond human language, including protein engineering, where pre-trained protein language models (PLMs) have demonstrated remarkable success. However, interdisciplinary adoption remains limited due to challenges in data collection, task benchmarking, and application. This work presents VenusFactory, a versatile engine that integrates biological data retrieval, standardized task benchmarking, and modular fine-tuning of PLMs. VenusFactory supports both computer science and biology communities with choices of both a command-line execution and a Gradio-based no-code interface, integrating 40+ protein-related datasets and 40+ popular PLMs. All implementations are open-sourced on https://github.com/ai4protein/VenusFactory. A video introduction is available at https://www.youtube.com/watch?v=MT6lPH5kgCc.- Anthology ID:
- 2025.acl-demo.23
- Volume:
- Proceedings of the 63rd Annual Meeting of the Association for Computational Linguistics (Volume 3: System Demonstrations)
- Month:
- July
- Year:
- 2025
- Address:
- Vienna, Austria
- Editors:
- Pushkar Mishra, Smaranda Muresan, Tao Yu
- Venue:
- ACL
- SIG:
- Publisher:
- Association for Computational Linguistics
- Note:
- Pages:
- 230–241
- Language:
- URL:
- https://preview.aclanthology.org/ingestion-acl-25/2025.acl-demo.23/
- DOI:
- Cite (ACL):
- Yang Tan, Chen Liu, Jingyuan Gao, Wu Banghao, Mingchen Li, Ruilin Wang, Lingrong Zhang, Huiqun Yu, Guisheng Fan, Liang Hong, and Bingxin Zhou. 2025. VenusFactory: An Integrated System for Protein Engineering with Data Retrieval and Language Model Fine-Tuning. In Proceedings of the 63rd Annual Meeting of the Association for Computational Linguistics (Volume 3: System Demonstrations), pages 230–241, Vienna, Austria. Association for Computational Linguistics.
- Cite (Informal):
- VenusFactory: An Integrated System for Protein Engineering with Data Retrieval and Language Model Fine-Tuning (Tan et al., ACL 2025)
- PDF:
- https://preview.aclanthology.org/ingestion-acl-25/2025.acl-demo.23.pdf