LitTx: A New Treatment Relation Extraction Dataset

Yuhang Jiang, Md Sultan Al Nahian, Li Hao Richie Xu, Rani Chikkanna, Ramakanth Kavuluru


Abstract
The interest in biomedical relation extraction (RE) continues to persist even in the LLM era owing to RE being a prominent way to build knowledge graphs, which further ground LLM applications, especially in preventing hallucinations. Therapy-disease treatment relations from scientific literature are an important type in RE as they indicate emerging therapeutic hypotheses and off-label usages being explored in the community. An automatically extracted evolving knowledge-base of such relations will be of great utility to researchers because doing it manually is not viable with the exponential growth of biomedical articles. In this paper, toward this end, we introduce a new expert-annotated dataset LitTx for identifying treatment relationships discussed in literature given the lack of such datasets in the recent past. Besides confirmed or implied positive relations, we also introduce a new "conditional treatment" relation type where hedging or a potential relationship is indicated. Our baseline RE models with this new dataset demonstrate promising results, while also revealing clear areas for improvement. To foster innovation and ensure replicability in the biomedical RE community, we release our dataset, code, and annotation guidelines publicly: https://github.com/bionlproc/LitTx_dataset.
Anthology ID:
2026.lrec-main.105
Volume:
Proceedings of the Fifteenth Language Resources and Evaluation Conference
Month:
May
Year:
2026
Address:
Palma de Mallorca, Spain
Editors:
Stelios Piperidis, Núria Bel, Henk van den Heuvel, Nancy Ide, Simon Krek, Antonio Toral
Venue:
LREC
SIG:
Publisher:
ELRA Language Resource Association
Note:
Pages:
1352–1360
Language:
URL:
https://preview.aclanthology.org/ingest-lrec/2026.lrec-main.105/
DOI:
Bibkey:
Cite (ACL):
Yuhang Jiang, Md Sultan Al Nahian, Li Hao Richie Xu, Rani Chikkanna, and Ramakanth Kavuluru. 2026. LitTx: A New Treatment Relation Extraction Dataset. International Conference on Language Resources and Evaluation, main:1352–1360.
Cite (Informal):
LitTx: A New Treatment Relation Extraction Dataset (Jiang et al., LREC 2026)
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PDF:
https://preview.aclanthology.org/ingest-lrec/2026.lrec-main.105.pdf