Automated Coding of Counsellor and Client Behaviours in Motivational Interviewing Transcripts: Validation and Application

Armaity Katki, Nathan Choi, Son Sophak Otra, George Flint, Kevin Zhu, Sunishchal Dev


Abstract
Protein language models (PLMs) are powerful tools for protein engineering, but remain difficult to steer toward specific biochemical properties, where small sequence changes can affect stability or function. We adapt two prominent unsupervised editing methods: task arithmetic (TA; specifically, Forgetting via Negation) in weight space and feature editing with a sparse autoencoder (SAE) in activation space. We evaluate their effects on six biochemical properties of generations from three PLMs (ESM3, ProGen2-Large, and ProLLaMA). Across models, we observe complementary efficacies: TA more effectively controls some properties while SAE more effectively controls others. Property response patterns show some consistence across models. We suggest that the response pattern of biochemical properties should be considered when steering PLMs.
Anthology ID:
2025.nlpai4health-main.4
Volume:
NLP-AI4Health
Month:
December
Year:
2025
Address:
Mumbai, India
Editors:
Parameswari Krishnamurthy, Vandan Mujadia, Dipti Misra Sharma, Hannah Mary Thomas
Venues:
NLP-AI4Health | WS
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Publisher:
Association for Computational Linguistics
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Pages:
25–54
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URL:
https://preview.aclanthology.org/ingest-ijcnlp-aacl/2025.nlpai4health-main.4/
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Cite (ACL):
Armaity Katki, Nathan Choi, Son Sophak Otra, George Flint, Kevin Zhu, and Sunishchal Dev. 2025. Automated Coding of Counsellor and Client Behaviours in Motivational Interviewing Transcripts: Validation and Application. In NLP-AI4Health, pages 25–54, Mumbai, India. Association for Computational Linguistics.
Cite (Informal):
Automated Coding of Counsellor and Client Behaviours in Motivational Interviewing Transcripts: Validation and Application (Katki et al., NLP-AI4Health 2025)
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https://preview.aclanthology.org/ingest-ijcnlp-aacl/2025.nlpai4health-main.4.pdf