We introduce Agentic Reasoning, a framework that enhances large language model (LLM) reasoning by integrating external tool-using agents. Agentic Reasoning dynamically leverages web search, code execution, and structured memory to address complex problems requiring deep research. A key innovation in our framework is the Mind-Map agent, which constructs a structured knowledge graph to store reasoning context and track logical relationships, ensuring coherence in long reasoning chains with extensive tool usage. Additionally, we conduct a comprehensive exploration of the Web-Search agent, leading to a highly effective search mechanism that surpasses all prior approaches. When deployed on DeepSeek-R1, our method achieves a new state-of-the-art (SOTA) among public models and delivers performance comparable to OpenAI Deep Research, the leading proprietary model in this domain. Extensive ablation studies validate the optimal selection of agentic tools and confirm the effectiveness of our Mind-Map and Web-Search agents in enhancing LLM reasoning. Our code and data are publicly available.

The severe shortage of medical doctors limits access to timely and reliable healthcare, leaving millions underserved. Large language models (LLMs) offer a potential solution but struggle in real-world clinical interactions. Many LLMs are not grounded in authoritative medical guidelines and fail to transparently manage diagnostic uncertainty. Their language is often rigid and mechanical, lacking the human-like qualities essential for patient trust. To address these challenges, we propose ***Ask Patients with Patience (APP)***, a multi-turn LLM-based medical assistant designed for grounded reasoning, transparent diagnoses, and human-centric interaction. APP enhances communication by eliciting user symptoms through empathetic dialogue, significantly improving accessibility and user engagement. It also incorporates Bayesian active learning to support transparent and adaptive diagnoses. The framework is built on verified medical guidelines, ensuring clinically grounded and evidence-based reasoning. To evaluate its performance, we develop a new benchmark that simulates realistic medical conversations using patient agents driven by profiles extracted from real-world consultation cases. We compare APP against SOTA one-shot and multi-turn LLM baselines. The results show that APP improves diagnostic accuracy, reduces uncertainty, and enhances user experience. By integrating medical expertise with transparent, human-like interaction, APP bridges the gap between AI-driven medical assistance and real-world clinical practice.