Recent advancements in Large Vision Language Models (LVLMs) show promise for pathological diagnosis, yet their application in clinical settings faces critical challenges of multimodal hallucination and biased responses. While preference alignment methods have proven effective in general domains, acquiring high-quality preference data for pathology remains challenging due to limited expert resources and domain complexity. In this paper, we propose EAGLE (Expert-guided self-enhancement for preference Alignment in patholoGy Large vision-languagE model), a novel framework that systematically integrates medical expertise into preference alignment. EAGLE consists of three key stages: initialization through supervised fine-tuning, self-preference creation leveraging expert prompting and medical entity recognition, and iterative preference following-tuning. The self-preference creation stage uniquely combines expert-verified chosen sampling with expert-guided rejected sampling to generate high-quality preference data, while the iterative tuning process continuously refines both data quality and model performance. Extensive experiments demonstrate that EAGLE significantly outperforms existing pathological LVLMs, effectively reducing hallucination and bias while maintaining pathological accuracy. The source code is available at https://github.com/meidandz/EAGLE.

With the rise of mental health challenges, social media has become a key platform for emotional expression. Deep learning offers a promising solution for analyzing mental health but lacks flexibility and interpretability. Large language models (LLMs) introduce greater adaptability and can explain their decisions, yet they still underperform deep learning in complex psychological analysis. We present C-IMHI, the first multi-task Chinese social media interpretable mental health instruction dataset (9K samples) with quality control and manual validation. Additionally, we introduce MentalGLM, the first open-source Chinese LLMs for explainable mental health analysis, trained on 50K instructions. The proposed models excelled in three mental health downstream tasks, outperforming or matching deep learning and LLMs. A portion of the generated decision explanations was validated by experts, demonstrating promising accuracy and reliability. We evaluated the proposed models on a clinical dataset, where they significantly outperformed other LLMs, demonstrating their potential for clinical applications. Our models show strong performance, validated across tasks and domains. The decision explanations enhance usability and facilitate better understanding and practical application of the models. Both the constructed dataset and the models are publicly available via: https://github.com/zwzzzQAQ/MentalGLM.