Large language models hold promise for addressing medical challenges, such as medical diagnosis reasoning, research knowledge acquisition, clinical decision-making, and consumer health inquiry support. However, they often generate hallucinations due to limited medical knowledge. Incorporating external knowledge is therefore critical, which necessitates multi-source knowledge acquisition. We address this challenge by framing it as a source planning problem, which is to formulate context-appropriate queries tailored to the attributes of diverse sources. Existing approaches either overlook source planning or fail to achieve it effectively due to misalignment between the model’s expectation of the sources and their actual content. To bridge this gap, we present MedOmniKB, a repository comprising multigenre and multi-structured medical knowledge sources. Leveraging these sources, we propose the Source Planning Optimisation method, which enhances multi-source utilisation. Our approach involves enabling an expert model to explore and evaluate potential plans while training a smaller model to learn source alignment. Experimental results demonstrate that our method substantially improves multi-source planning performance, enabling the optimised small model to achieve state-of-the-art results in leveraging diverse medical knowledge sources.

The reliability of large language models remains a critical challenge, particularly due to their susceptibility to hallucinations and factual inaccuracies during text generation. Existing solutions either underutilize models’ self-correction with preemptive strategies or use costly post-hoc verification. To further explore the potential of real-time self-verification and correction, we present Dynamic Self-Verify Decoding (DSVD), a novel decoding framework that enhances generation reliability through real-time hallucination detection and efficient error correction. DSVD integrates two key components: (1) parallel self-verification architecture for continuous quality assessment, (2) dynamic rollback mechanism for targeted error recovery. Extensive experiments across five benchmarks demonstrate DSVD’s effectiveness, achieving significant improvement in truthfulness (Quesetion-Answering) and factual accuracy (FActScore). Results show the DSVD can be further incorporated with existing faithful decoding methods to achieve stronger performance. Our work establishes that real-time self-verification during generation offers a viable path toward more trustworthy language models without sacrificing practical deployability.

Heart sound auscultation holds significant importance in the diagnosis of congenital heart disease. However, existing methods for Heart Sound Diagnosis (HSD) tasks are predominantly limited to a few fixed categories, framing the HSD task as a rigid classification problem that does not fully align with medical practice and offers only limited information to physicians. Besides, such methods do not utilize echocardiography reports, the gold standard in the diagnosis of related diseases. To tackle this challenge, we introduce HSDreport, a new benchmark for HSD, which mandates the direct utilization of heart sounds obtained from auscultation to predict echocardiography reports. This benchmark aims to merge the convenience of auscultation with the comprehensive nature of echocardiography reports. First, we collect a new dataset for this benchmark, comprising 2,275 heart sound samples along with their corresponding reports. Subsequently, we develop a knowledge-aware query-based transformer to handle this task. The intent is to leverage the capabilities of medically pre-trained models and the internal knowledge of large language models (LLMs) to address the task’s inherent complexity and variability, thereby enhancing the robustness and scientific validity of the method. Furthermore, our experimental results indicate that our method significantly outperforms traditional HSD approaches and existing multimodal LLMs in detecting key abnormalities in heart sounds.

The Video-Grounded Dialogue generation (VDG) is a challenging task requiring a comprehensive understanding of the multi-modal information to produce a pertinent response. However, VDG models may rely on dataset bias as a shortcut and fail to learn the multi-modal knowledge from both video and audio. Counterfactual reasoning is an effective method that can estimate and eliminate bias on some special aspects of classification tasks. However, conventional counterfactual reasoning cannot be applied to VDG tasks directly due to the BPE algorithm. In this paper, we reformulate the counterfactual reasoning from the information entropy perspective and extend it from the classification task to the generative task, which can effectively reduce the question-related bias in the auto-regressive generation task. We design CE-VDG to demonstrate the effectiveness in bias elimination of the reformulated counterfactual reasoning by using the proposed counterfactual entropy as an external loss. Extensive experiment results on two popular VDG datasets show the superiority of CE-VDG over the existing baseline method, demonstrating the effective debiasing capability in our model considering counterfactual entropy.

Structured pruning is an effective technique for compressing pre-trained language models (PLMs), reducing model size and improving inference speed for efficient deployment. However, most of existing pruning algorithms require retraining, leading to additional computational overhead. While some retraining-free approaches have been proposed for classification tasks, they still require a fully fine-tuned model for the task, and may cause catastrophic performance degradation on generative tasks. To address these challenges, we propose P-pruning (pre-pruning), an innovative task-specific compression framework. P-pruning prunes redundant modules of PLMs before fine-tuning, reducing the costs associated with fine-tuning. We also introduce a pruning algorithm for this framework, which includes two techniques: (1) module clustering, which clusters the outputs of all heads and neurons based on the task input; and (2) centroid selection, which identifies the most salient element in each cluster and prunes the others. We apply our method to BERT and GPT-2 and evaluate its effectiveness on GLUE, SQuAD, WikiText-2, WikiText-103, and PTB datasets. Experimental results demonstrate that our approach achieves higher performance in both classification and generative tasks, while also reducing the time required for fine-tuning.