Large language models (LLMs) have shown significant promise in embodied decision-making tasks within virtual open-world environments. Nonetheless, their performance is hindered by the absence of domain-specific knowledge. Methods that finetune on large-scale domain-specific data entail prohibitive development costs. This paper introduces VistaWise, a cost-effective agent framework that integrates cross-modal domain knowledge and finetunes a dedicated object detection model for visual analysis. It reduces the requirement for domain-specific training data from millions of samples to a few hundred. VistaWise integrates visual information and textual dependencies into a cross-modal knowledge graph (KG), enabling a comprehensive and accurate understanding of multimodal environments. We also equip the agent with a retrieval-based pooling strategy to extract task-related information from the KG, and a desktop-level skill library to support direct operation of the Minecraft desktop client via mouse and keyboard inputs. Experimental results demonstrate that VistaWise achieves state-of-the-art performance across various open-world tasks, highlighting its effectiveness in reducing development costs while enhancing agent performance.