The deployment of Large Language Models (LLMs) faces significant challenges due to high computational costs,driving the demand for effective pruning techniques. Existing structured pruning methods employ uniform compression rates across network layers, neglecting the varying importance of different network depths. To address this limitation, we propose a novel optimization framework that directly minimizes global capability loss through layer-adaptive pruning rates. The framework formulates the pruning task as a combinatorial optimization problem constrained by a total parameter budget, and an efficient dynamic programming solution is derived to determine optimal layer-wise compression rates.Experiments demonstrate that, when tuning is not included, our approach achieves comparable performance with state-of-the-art methods at high pruning rates (37-50% reduction), and shows significant advantages at low pruning rates (13-25% reduction). When tuning is included, our method achieves the best performance among the compared methods.

Evidence-based medicine (EBM) is at the forefront of modern healthcare, emphasizing the use of the best available scientific evidence to guide clinical decisions. Due to the sheer volume and rapid growth of medical literature and the high cost of curation, there is a critical need to investigate Natural Language Processing (NLP) methods to identify, appraise, synthesize, summarize, and disseminate evidence in EBM. This survey presents an in-depth review of 129 research studies on leveraging NLP for EBM, illustrating its pivotal role in enhancing clinical decision-making processes. The paper systematically explores how NLP supports the five fundamental steps of EBM—Ask, Acquire, Appraise, Apply, and Assess. The review not only identifies current limitations within the field but also proposes directions for future research, emphasizing the potential for NLP to revolutionize EBM by refining evidence extraction, evidence synthesis, appraisal, summarization, enhancing data comprehensibility, and facilitating a more efficient clinical workflow.