The proliferation of misinformation in digital platforms reveals the limitations of traditional detection methods, which mostly rely on static classification and fail to capture the intricate process of real-world fact-checking. Despite advancements in Large Language Models (LLMs) that enhance automated reasoning, their application to misinformation detection remains hindered by issues of logical inconsistency and superficial verification. Inspired by the idea that “Truth Becomes Clearer Through Debate”, we introduce Debate-to-Detect (D2D), a novel Multi-Agent Debate (MAD) framework that reformulates misinformation detection as a structured adversarial debate. Based on fact-checking workflows, D2D assigns domain-specific profiles to each agent and orchestrates a five-stage debate process, including Opening Statement, Rebuttal, Free Debate, Closing Statement, and Judgment. To transcend traditional binary classification, D2D introduces a multi-dimensional evaluation mechanism that assesses each claim across five distinct dimensions: Factuality, Source Reliability, Reasoning Quality, Clarity, and Ethics. Experiments with GPT-4o on two fakenews datasets demonstrate significant improvements over baseline methods, and the case study highlight D2D’s capability to iteratively refine evidence while improving decision transparency, representing a substantial advancement towards robust and interpretable misinformation detection. Our code is available at https://github.com/hanshenmesen/Debate-to-Detect