Thesis proposal: COGNILENS: Analyzing Cognitive Decline in Language Models for Alzheimer’s Monitoring

Jonathan Guerne


Abstract
This research proposal describes a cross-disciplinary project aimed at developing Digital Twins (DTs) of Alzheimer’s Disease (AD) using Language Models (LMs). By mimicking the functional deficits observed in individuals with AD, these DTs will serve as tools for early detection and understanding of disease progression. Several approaches to altering the LM will be explored, and the resulting effects on brain score — an evaluation of the correlation between brain activity and the LM’s internal activations — will be studied. Detection models will be trained based on each approach; these models will be compared against themselves and the state-of-the-art.Two converging lines of evidence motivate this work: LMs achieve high accuracy in classifying AD from speech transcripts, and their internal representations correlate significantly with human brain activity during language processing. If successful, this project could lead to significant advancements in the early detection and monitoring of AD, ultimately improving patient outcomes.
Anthology ID:
2026.eacl-srw.12
Volume:
Proceedings of the 19th Conference of the European Chapter of the Association for Computational Linguistics (Volume 4: Student Research Workshop)
Month:
March
Year:
2026
Address:
Rabat, Morocco
Editors:
Selene Baez Santamaria, Sai Ashish Somayajula, Atsuki Yamaguchi
Venue:
EACL
SIG:
Publisher:
Association for Computational Linguistics
Note:
Pages:
170–181
Language:
URL:
https://preview.aclanthology.org/ingest-eacl/2026.eacl-srw.12/
DOI:
Bibkey:
Cite (ACL):
Jonathan Guerne. 2026. Thesis proposal: COGNILENS: Analyzing Cognitive Decline in Language Models for Alzheimer’s Monitoring. In Proceedings of the 19th Conference of the European Chapter of the Association for Computational Linguistics (Volume 4: Student Research Workshop), pages 170–181, Rabat, Morocco. Association for Computational Linguistics.
Cite (Informal):
Thesis proposal: COGNILENS: Analyzing Cognitive Decline in Language Models for Alzheimer’s Monitoring (Guerne, EACL 2026)
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https://preview.aclanthology.org/ingest-eacl/2026.eacl-srw.12.pdf