While large language models (LLMs) have achieved state-of-the-art performance on a wide range of medical question answering (QA) tasks, they still face challenges with hallucinations and outdated knowledge. Retrieval-augmented generation (RAG) is a promising solution and has been widely adopted. However, a RAG system can involve multiple flexible components, and there is a lack of best practices regarding the optimal RAG setting for various medical purposes. To systematically evaluate such systems, we propose the Medical Information Retrieval-Augmented Generation Evaluation (MIRAGE), a first-of-its-kind benchmark including 7,663 questions from five medical QA datasets. Using MIRAGE, we conducted large-scale experiments with over 1.8 trillion prompt tokens on 41 combinations of different corpora, retrievers, and backbone LLMs through the MedRAG toolkit introduced in this work. Overall, MedRAG improves the accuracy of six different LLMs by up to 18% over chain-of-thought prompting, elevating the performance of GPT-3.5 and Mixtral to GPT-4-level. Our results show that the combination of various medical corpora and retrievers achieves the best performance. In addition, we discovered a log-linear scaling property and the “lost-in-the-middle” effects in medical RAG. We believe our comprehensive evaluations can serve as practical guidelines for implementing RAG systems for medicine.

Visually-rich document entity retrieval (VDER), which extracts key information (e.g. date, address) from document images like invoices and receipts, has become an important topic in industrial NLP applications. The emergence of new document types at a constant pace, each with its unique entity types, presents a unique challenge: many documents contain unseen entity types that occur only a couple of times. Addressing this challenge requires models to have the ability of learning entities in a few-shot manner. However, prior works for Few-shot VDER mainly address the problem at the document level with a predefined global entity space, which doesn’t account for the entity-level few-shot scenario: target entity types are locally personalized by each task and entity occurrences vary significantly among documents. To address this unexplored scenario, this paper studies a novel entity-level few-shot VDER task. The challenges lie in the uniqueness of the label space for each task and the increased complexity of out-of-distribution (OOD) contents. To tackle this novel task, we present a task-aware meta-learning based framework, with a central focus on achieving effective task personalization that distinguishes between in-task and out-of-task distribution. Specifically, we adopt a hierarchical decoder (HC) and employ contrastive learning (ContrastProtoNet) to achieve this goal. Furthermore, we introduce a new dataset, FewVEX, to boost future research in the field of entity-level few-shot VDER. Experimental results demonstrate our approaches significantly improve the robustness of popular meta-learning baselines.