This paper provides an overview of NVIDIA NeMo’s speech translation systems for the IWSLT 2022 Offline Speech Translation Task. Our cascade system consists of 1) Conformer RNN-T automatic speech recognition model, 2) punctuation-capitalization model based on pre-trained T5 encoder, 3) ensemble of Transformer neural machine translation models fine-tuned on TED talks. Our end-to-end model has less parameters and consists of Conformer encoder and Transformer decoder. It relies on the cascade system by re-using its pre-trained ASR encoder and training on synthetic translations generated with the ensemble of NMT models. Our En->De cascade and end-to-end systems achieve 29.7 and 26.2 BLEU on the 2020 test set correspondingly, both outperforming the previous year’s best of 26 BLEU.