Achieving seamless, human-like interaction remains a key challenge for full-duplex spoken dialogue models (SDMs). Reinforcement learning (RL) has substantially enhanced text- and vision-language models, while well-designed reward signals are crucial for the performance of RL. We consider RL a promising strategy to address the key challenge for SDMs. However, a fundamental barrier persists: prevailing automated metrics for assessing interaction quality rely on superficial proxies, such as behavioral statistics or timing-prediction accuracy, failing to provide reliable reward signals for RL. On the other hand, human evaluations, despite their richness, remain costly, inconsistent, and difficult to scale. We tackle this critical barrier by proposing a Dual-Axis Generative Reward Model, which is trained to understand complex interaction dynamics using a detailed taxonomy and an annotated dataset, produces a single score and, crucially, provides separate evaluations for semantic quality and interaction timing. Such dual outputs furnish precise diagnostic feedback for SDMs and deliver a dependable, instructive reward signal suitable for online reinforcement learning. Our model achieves state-of-the-art performance on interaction-quality assessment across a wide spectrum of datasets, spanning synthetic dialogues and complex real-world interactions.

End-to-end spoken dialogue models have garnered significant attention because they offer a higher potential ceiling in expressiveness and perceptual ability than cascaded systems. However, the intelligence and expressiveness of current open-source spoken dialogue models often remain below expectations. Motivated by the success of online reinforcement learning(RL) in other domains, one might attempt to directly apply preference optimization to spoken dialogue models, yet this transfer is non-trivial. We analyze these obstacles from the perspectives of reward modeling and rollout sampling, focusing on how sparse preference supervision interacts with dense speech generation under shared-parameter updates. Based on the analysis, we propose a modality-aware adaptive post-training recipe that makes RL practical for spoken dialogue: it constrains preference updates to the semantic channel and improves acoustic behavior via explicit anchoring, while dynamically regulating their mixture from rollout statistics to avoid unreliable preference gradients. We evaluate the method across multiple spoken dialogue benchmarks and representative architectures, and observe consistent improvements in semantic quality and speech expressiveness.

Large language models (LLMs) are introducing a paradigm shift in molecular discovery by enabling text-guided interaction with chemical spaces through natural language and symbolic notations, with emerging extensions to incorporate multi-modal inputs. To advance this emerging field, this survey provides an up-to-date and forward-looking review of the emerging use of LLMs for two central tasks: molecule generation and molecule optimization. We organize our survey around four fundamental challenges that have emerged as critical evaluation dimensions in recent studies: ensuring validity, enhancing synthesizability, achieving precise property control, and maximizing diversity. Based on this, we systematically analyze how current LLM learning paradigms are applied to tackle each challenge, revealing the distinct capabilities and inherent limitations of each approach. In addition, we include the commonly used datasets and evaluation protocols aligned with these challenges. We conclude by discussing future directions, positioning this survey as a resource for researchers working at the intersection of LLMs and molecular science. A continuously updated reading list is available at https://github.com/REAL-Lab-NU/Awesome-LLM-Centric-Molecular-Discovery.

In drug discovery, molecular optimization aims to iteratively refine a lead compound to improve molecular properties while preserving structural similarity to the original molecule. However, each oracle evaluation is expensive, making sample efficiency a key challenge for existing methods under a limited oracle budget. Trial-and-error approaches require many oracle calls, while methods that leverage external knowledge tend to reuse familiar templates and struggle on challenging objectives. A key missing piece is long-term memory that can ground decisions and provide reusable insights for future optimizations. To address this, we present MolMem (Molecular optimization with Memory), a multi-turn agentic reinforcement learning (RL) framework with a dual-memory system. Specifically, MolMem uses Static Exemplar Memory to retrieve relevant exemplars for cold-start grounding, and Evolving Skill Memory to distill successful trajectories into reusable strategies. Built on this memory-augmented formulation, we train the policy with dense step-wise rewards, turning costly rollouts into long-term knowledge that improves future optimization. Extensive experiments show that MolMem achieves 90% success on single-property tasks (1.5× over the best baseline) and 52% on multi-property tasks using only 500 oracle calls. Our code is available at https://github.com/REAL-Lab-NU/MolMem.

When large language models are used in real-world scenarios, continual learning (CL) becomes a non-trivial problem. In particular, continual learning with modern LLMs is challenged both by the substantial computational costs induced by their massive parameter scale, and by the limitations of current CL methods, which are mainly designed to mitigate catastrophic forgetting while neglecting knowledge sharing across tasks. We further observe that models with stronger performance exhibit stronger inter-task connections. In light of the above challenges and findings, we propose Attribution Scores-based Soft Orthogonality Low-Rank Adaptation (ASO-LoRA), an effective and efficient framework that simultaneously facilitates knowledge transfer while mitigating catastrophic forgetting. Specifically, ASO-LoRA initially assigns task-specific parameter subspaces for new tasks utilizing multi-LoRA modules, enabling for efficient training and inference without relying on task labels. Then, ASO-LoRA leverages attribution scores to evaluate task similarity and employs soft orthogonality between task-specific subspaces, guiding gradient updates in directions that promote parameter isolation, achieving a balance between knowledge transfer and preservation. Experiments are carried out on both the T5-large and the LLaMA2-7B, showing ASO-LoRA’s superior performance and suitability as a plug-in CL solution for general Transformer-based LLMs. Code is available at https://github.com/736619821/ASO-LORA.

Medical Multimodal Large Language Models (Med-MLLMs) have shown great promise in medical visual question answering (Med-VQA). However, when deployed in low-resource settings where abundant labeled data are unavailable, existing Med-MLLMs commonly fail due to their medical reasoning capability bottlenecks: (i) the intrinsic reasoning bottleneck that ignores the details from the medical image; (ii) the extrinsic reasoning bottleneck that fails to incorporate specialized medical knowledge. To address those limitations, we propose AMANDA, a training-free agentic framework that performs medical knowledge augmentation via LLM agents. Specifically, our intrinsic medical knowledge augmentation focuses on coarse-to-fine question decomposition for comprehensive diagnosis, while extrinsic medical knowledge augmentation grounds the reasoning process via biomedical knowledge graph retrieval. Extensive experiments across eight Med-VQA benchmarks demonstrate substantial improvements in both zero-shot and few-shot Med-VQA settings. The code is available at https://github.com/REAL-Lab-NU/AMANDA.

Spoken Dialogue Models (SDMs) have achieved significant progress in recent years, yet they continue to face challenges in handling nuanced interactional phenomena. A significant bottleneck hindering further advancement is the scarcity of publicly available, high-quality datasets meticulously designed to train and evaluate these fine-grained interactive capabilities. We introduce InteractSpeech, a 150-hour English speech interaction dialogue dataset designed to empower spoken dialogue models with nuanced real-time interaction capabilities, such as handling interruptions and backchannels. InteractSpeech was created by synthesizing interactive dialogues from text using advanced speech synthesis, and by filtering real-world spoken dialogues for interactive segments. The dataset features precise speaker timestamps and annotations for diverse dialogue interactions, underpinned by a formal framework for interaction dynamics. We demonstrate InteractSpeech’s utility by fine-tuning a LLaMA 3-8B model on its textual scenarios and, crucially, by training a speech understanding model that accurately classifies key interactional events directly from audio. This highlights the dataset’s value in developing models capable of more natural and responsive conversational turn-taking. Audio samples are available at https://interactspeech.github.io/.

Retrieval Augmented Generation (RAG) has gained widespread adoption owing to its capacity to empower large language models (LLMs) to integrate external knowledge. However, existing RAG frameworks are primarily designed for text-based LLMs and rely on Automatic Speech Recognition to process speech input, which discards crucial audio information, risks transcription errors, and increases computational overhead. Therefore, we introduce WavRAG, the first retrieval augmented generation framework with native, end-to-end audio support. WavRAG offers two key features: 1) Bypassing ASR, WavRAG directly processes raw audio for both embedding and retrieval. 2) WavRAG integrates audio and text into a unified knowledge representation. Specifically, we propose the WavRetriever to facilitate the retrieval from a text-audio hybrid knowledge base, and further enhance the in-context capabilities of spoken dialogue models through the integration of chain-of-thought reasoning. In comparison to state-of-the-art ASR-Text RAG pipelines, WavRAG achieves comparable retrieval performance while delivering a 10x acceleration. Furthermore, WavRAG’s unique text-audio hybrid retrieval capability extends the boundaries of RAG to the audio modality.