Self-deprecation is a prevalent communicative strategy in human society, often using image-text interplay to express emotions and intentions. Despite self-deprecation is widespread in real-world conversations, the ability of multimodal large language models (MLLMs) to understand it remains underexplored. To fill this gap, we introduce **JanusMM**, the first benchmark designed to evaluate MLLMs’ understanding of self-deprecation in real-world conversations. JanusMM contains 2,016 bilingual memes from three types of social interactions and provides a dual-task evaluation framework with six new metrics. The first task assesses MLLMs’ abilities in self-deprecation recognition and reasoning, while the second task evaluates the consistency of their understanding by simulating the perspectives of the initiator and responder. We evaluate ten frontier MLLMs and find that they exhibit weak recognition and reasoning abilities, with their understanding of self-deprecation remaining inconsistent across both perspectives.